PDM2A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDM2A_DROME
• UniProt AC: P31369
• Protein Name: POU domain protein 2, isoform A
• Gene Name: pdm2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 498
• Subcellular Localization: Nucleus.
• Protein Description: DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system..
• Protein Sequence: MMVLQQQQQQRLWDATTTSNTNTQTQQSANVESTPTKVCHQENAATHTFMRHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLSSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLHSYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTPLAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDSPTGTPLSSHAFGYPPQALNMSHMQMEGGSGSFCGSSISSGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	SLSDCGKSFEEEELE CHHHCCCCCHHHHHH	24.15	18327897
211	Phosphorylation	YSTPLAKSPLRSPSL CCCCCCCCCCCCCCC	24.45	18327897
215	Phosphorylation	LAKSPLRSPSLSPVP CCCCCCCCCCCCCCC	26.90	18327897
217	Phosphorylation	KSPLRSPSLSPVPRH CCCCCCCCCCCCCCC	42.60	18327897
219	Phosphorylation	PLRSPSLSPVPRHSK CCCCCCCCCCCCCCC	28.34	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDM2A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDM2A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDM2A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUMB_DROME	numb	genetic	14973280
PDM1_DROME	nub	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-211; SER-215;SER-217 AND SER-219, AND MASS SPECTROMETRY.
PubMed: 18327897