PCL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCL1_ARATH
• UniProt AC: Q9SNB4
• Protein Name: Transcription factor LUX
• Gene Name: LUX
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 323
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcriptional feedback circuit, by binding specific sites on PRR9 promoter. Binds to its own promoter, inducing a negative auto-regulatory feedback loop within the core clock. Binds to ELF3 and associates with ELF4 in a diurnal complex which is required for the expression of the growth-promoting transcription factors PIF4 and PIF5 and subsequent hypocotyl growth in the early evening..
• Protein Sequence: MGEEVQMSDYDVSGDGDRVSEWEMGLPSDEDLASLSYSLIPPNLAMAFSITPERSRTIQDVNRASETTLSSLRGGSSGPNTSSSNNNVEEEDRVGSSSPGSDSKKQKTSNGDGDDGGGVDPDSAMAAEEGDSGTEDLSGKTLKRPRLVWTPQLHKRFVDVVAHLGIKNAVPKTIMQLMNVEGLTRENVASHLQKYRLYLKRMQGLTNEGPSASDKLFSSTPVPPQSFQDIGGGGGSSGNVGVPIPGAYGTQQMMQMPVYAHHMGMQGYHHQNHNHDPYHQNHRHHHGAGGNGAFESNPYMMQQNKFGSMASYPSVGGGSANEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	LSSLRGGSSGPNTSS HHHHCCCCCCCCCCC		23776212
77	Phosphorylation	SSLRGGSSGPNTSSS HHHCCCCCCCCCCCC		23776212
81	Phosphorylation	GGSSGPNTSSSNNNV CCCCCCCCCCCCCCC		23776212
82	Phosphorylation	GSSGPNTSSSNNNVE CCCCCCCCCCCCCCC		23776212
83	Phosphorylation	SSGPNTSSSNNNVEE CCCCCCCCCCCCCCH		23776212
84	Phosphorylation	SGPNTSSSNNNVEEE CCCCCCCCCCCCCHH		23776212
96	Phosphorylation	EEEDRVGSSSPGSDS CHHHCCCCCCCCCCC		23776212
97	Phosphorylation	EEDRVGSSSPGSDSK HHHCCCCCCCCCCCC		23776212
98	Phosphorylation	EDRVGSSSPGSDSKK HHCCCCCCCCCCCCC		23776212
101	Phosphorylation	VGSSSPGSDSKKQKT CCCCCCCCCCCCCCC		23776212
103	Phosphorylation	SSSPGSDSKKQKTSN CCCCCCCCCCCCCCC		23776212
123	Phosphorylation	GGGVDPDSAMAAEEG CCCCCHHHHHHHHCC		30407730
132	Phosphorylation	MAAEEGDSGTEDLSG HHHHCCCCCCCCCCC		19880383
134	Phosphorylation	AEEGDSGTEDLSGKT HHCCCCCCCCCCCCC		19880383
138	Phosphorylation	DSGTEDLSGKTLKRP CCCCCCCCCCCCCCC		30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCL1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELF3_ARATH	ELF3	physical	21753751
ELF4_ARATH	ELF4	physical	21753751

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.