PAXI_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAXI_CHICK
• UniProt AC: P49024
• Protein Name: Paxillin
• Gene Name: PXN
• Organism: Gallus gallus (Chicken).
• Sequence Length: 559
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell junction, focal adhesion.
• Protein Description: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK..
• Protein Sequence: MDDLDALLADLESTTSHISKRPVFLTEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVIDPLDQWQPSVSRYGHQQPQSQSPIYSSSAKSSSASVPRDGLSSPSPRASEEEHVYSFPNKQKSAEPSPTMTSTSLGSNLSELDRLLLELNAVQHNPPSGFSADEVSRSPSLPNVTGPHYVIPESSSSAGGKAAPPTKEKPKRNGGRGIEDVRPSVESLLDELESSVPSPVPAITVSQGEVSSPQRVNASQQQTRISASSATRELDELMASLSDFKFMAQGKAGGSSSPPSTTPKPGSQLDTMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGVFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFINGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMGKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	PVFLTEETPYSYPTG CEEECCCCCCCCCCC	22.69	-
31	Phosphorylation	FLTEETPYSYPTGNH EECCCCCCCCCCCCC	28.40	-
40	Phosphorylation	YPTGNHTYQEIAVPP CCCCCCEEEEEECCC	9.15	-
76	Phosphorylation	WQPSVSRYGHQQPQS CCCCHHHCCCCCCCC	16.08	-
83	Phosphorylation	YGHQQPQSQSPIYSS CCCCCCCCCCCCCCC	39.03	-
85	Phosphorylation	HQQPQSQSPIYSSSA CCCCCCCCCCCCCCC	20.64	23106611
88	Phosphorylation	PQSQSPIYSSSAKSS CCCCCCCCCCCCCCC	13.09	-
89	Phosphorylation	QSQSPIYSSSAKSSS CCCCCCCCCCCCCCC	20.66	-
90	Phosphorylation	SQSPIYSSSAKSSSA CCCCCCCCCCCCCCC	19.83	-
91	Phosphorylation	QSPIYSSSAKSSSAS CCCCCCCCCCCCCCC	33.50	-
94	Phosphorylation	IYSSSAKSSSASVPR CCCCCCCCCCCCCCC	29.28	-
95	Phosphorylation	YSSSAKSSSASVPRD CCCCCCCCCCCCCCC	29.26	-
96	Phosphorylation	SSSAKSSSASVPRDG CCCCCCCCCCCCCCC	31.49	-
98	Phosphorylation	SAKSSSASVPRDGLS CCCCCCCCCCCCCCC	34.30	-
106	Phosphorylation	VPRDGLSSPSPRASE CCCCCCCCCCCCCCC	34.14	-
108	Phosphorylation	RDGLSSPSPRASEEE CCCCCCCCCCCCCCC	29.03	-
112	Phosphorylation	SSPSPRASEEEHVYS CCCCCCCCCCCCCCC	46.98	-
118	Phosphorylation	ASEEEHVYSFPNKQK CCCCCCCCCCCCCCC	13.40	23106611
119	Phosphorylation	SEEEHVYSFPNKQKS CCCCCCCCCCCCCCC	32.89	23106611
126	Phosphorylation	SFPNKQKSAEPSPTM CCCCCCCCCCCCCCC	35.06	23106611
130	Phosphorylation	KQKSAEPSPTMTSTS CCCCCCCCCCCCCCC	25.22	23106611
132	Phosphorylation	KSAEPSPTMTSTSLG CCCCCCCCCCCCCCC	37.10	23106611
134	Phosphorylation	AEPSPTMTSTSLGSN CCCCCCCCCCCCCCC	31.19	23106611
135	Phosphorylation	EPSPTMTSTSLGSNL CCCCCCCCCCCCCCH	12.74	23106611
137	Phosphorylation	SPTMTSTSLGSNLSE CCCCCCCCCCCCHHH	30.42	-
143	Phosphorylation	TSLGSNLSELDRLLL CCCCCCHHHHHHHHH	40.12	-
164	Phosphorylation	HNPPSGFSADEVSRS CCCCCCCCHHHHHCC	38.03	-
171	Phosphorylation	SADEVSRSPSLPNVT CHHHHHCCCCCCCCC	16.01	23106611
173	Phosphorylation	DEVSRSPSLPNVTGP HHHHCCCCCCCCCCC	58.67	23106611
182	Phosphorylation	PNVTGPHYVIPESSS CCCCCCCEECCCCCC	11.83	-
187	Phosphorylation	PHYVIPESSSSAGGK CCEECCCCCCCCCCC	30.11	-
188	Phosphorylation	HYVIPESSSSAGGKA CEECCCCCCCCCCCC	27.01	-
189	Phosphorylation	YVIPESSSSAGGKAA EECCCCCCCCCCCCC	33.22	-
190	Phosphorylation	VIPESSSSAGGKAAP ECCCCCCCCCCCCCC	32.64	-
199	Phosphorylation	GGKAAPPTKEKPKRN CCCCCCCCCCCCCCC	51.26	-
217	Phosphorylation	GIEDVRPSVESLLDE CHHHHCHHHHHHHHH	28.14	-
220	Phosphorylation	DVRPSVESLLDELES HHCHHHHHHHHHHHH	31.88	-
227	Phosphorylation	SLLDELESSVPSPVP HHHHHHHHCCCCCCC	49.62	-
228	Phosphorylation	LLDELESSVPSPVPA HHHHHHHCCCCCCCE	28.77	-
231	Phosphorylation	ELESSVPSPVPAITV HHHHCCCCCCCEEEE	36.05	-
239	Phosphorylation	PVPAITVSQGEVSSP CCCEEEEECCCCCCC	24.66	-
245	Phosphorylation	VSQGEVSSPQRVNAS EECCCCCCCCCCCHH	30.17	-
259	Phosphorylation	SQQQTRISASSATRE HHHHHHHCCHHHHHH	20.86	23106611
262	Phosphorylation	QTRISASSATRELDE HHHHCCHHHHHHHHH	33.12	-
273	Phosphorylation	ELDELMASLSDFKFM HHHHHHHHHCCCCHH	17.91	-
275	Phosphorylation	DELMASLSDFKFMAQ HHHHHHHCCCCHHHC	38.21	-
288	Phosphorylation	AQGKAGGSSSPPSTT HCCCCCCCCCCCCCC	27.07	23106611
289	Phosphorylation	QGKAGGSSSPPSTTP CCCCCCCCCCCCCCC	50.57	23106611
290	Phosphorylation	GKAGGSSSPPSTTPK CCCCCCCCCCCCCCC	42.39	23106611
295	Phosphorylation	SSSPPSTTPKPGSQL CCCCCCCCCCCCCHH	33.38	-
308	Phosphorylation	QLDTMLGSLQSDLNK HHHHHHHHHHHHHHH	21.19	-
344	Phosphorylation	VVTAMGKTWHPEHFV EEECCCCCCCCHHCE	24.23	-
361	Phosphorylation	HCQEEIGSRNFFERD CCCHHHCCCCCCCCC	29.70	-
377	Phosphorylation	QPYCEKDYHNLFSPR CCCCCCCCHHCCCCC	12.04	-
382	Phosphorylation	KDYHNLFSPRCYYCN CCCHHCCCCCEEEEC	18.01	-
398	Phosphorylation	PILDKVVTALDRTWH HHHHHHHHHHHHCCC	25.21	-
403	Phosphorylation	VVTALDRTWHPEHFF HHHHHHHCCCHHHEE	28.00	-
436	Phosphorylation	KAYCRKDYFDMFAPK CEEECHHHHHHCCCC	12.43	-
457	Phosphorylation	AILENYISALNTLWH HHHHHHHHHHHHCCC	19.15	-
481	Phosphorylation	FTPFINGSFFEHDGQ CCCCCCCCCEEECCC	23.44	-
501	Phosphorylation	HYHERRGSLCSGCQK EEECCCCCCCCCCCC	25.13	-
504	Phosphorylation	ERRGSLCSGCQKPIT CCCCCCCCCCCCCCC	48.15	-
540	Phosphorylation	LKQLNKGTFKEQNDK HHHHCCCCCCCCCCC	32.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	Y	Phosphorylation	Kinase	SRC	P00523	PSP
40	Y	Phosphorylation	Kinase	SRC	P00523	PSP
88	Y	Phosphorylation	Kinase	SRC	P00523	PSP
118	Y	Phosphorylation	Kinase	FAK1	Q00944	Uniprot
118	Y	Phosphorylation	Kinase	PTK2	Q05397	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAXI_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAXI_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIRR_CHICK	NUDT16L1	physical	11805099
VINC_CHICK	VCL	physical	7525621
FAK1_CHICK	PTK2	physical	7525621

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.