| UniProt ID | PARG_DROME | |
|---|---|---|
| UniProt AC | O46043 | |
| Protein Name | Poly(ADP-ribose) glycohydrolase | |
| Gene Name | Parg | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 723 | |
| Subcellular Localization | ||
| Protein Description | Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.. | |
| Protein Sequence | MSKSPDGGISEIETEEEPENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAGNLHRVMYQLPIRETPPRPYKSPGKWDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERALLQPIKTCEELQAAIISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDLIQSPVPLLKHHKNASLSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPAVLEKLKCIMHYFRRVCPTERDASNVPTGVVTFVRRSGLPEHLIDWSQSAAPLGDVPLHVDAEGTIEDEGIGLLQVDFANKYLGGGVLGHGCVQEEIRFVICPELLVGKLFTECLRPFEALVMLGAERYSNYTGYAGSFEWSGNFEDSTPRDSSGRRQTAIVAIDALHFAQSHHQYREDLMERELNKAYIGFVHWMVTPPPGVATGNWGCGAFGGDSYLKALLQLMVCAQLGRPLAYYTFGNVEFRDDFHEMWLLFRNDGTTVQQLWSILRSYSRLIKEKSSKEPRENKASKKKLYDFIKEELKKVRDVPGEGASAEAGSSRVAGLGEGKSETSAKSSPELNKQPARPQITITQQSTDLLPAQLSQDNSNSSEDQALLMLSDDEEANAMMEAASLEAKSSVEISNSSTTSKTSSTATKSMGSGGRQLSLLEMLDTHYEKGSASKRPRKSPNCSKAEGSAKSRKEIDVTDKDEKDDIVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | EPENLANSLDDSWRG CHHHHHHHCCCCCCC | 38.02 | 22817900 | |
| 28 | Phosphorylation | LANSLDDSWRGVSME HHHHCCCCCCCCCHH | 11.59 | 22817900 | |
| 69 | Phosphorylation | YQLPIRETPPRPYKS EECCCCCCCCCCCCC | 27.80 | 18327897 | |
| 73 | Phosphorylation | IRETPPRPYKSPGKW CCCCCCCCCCCCCCC | 20.52 | 18327897 | |
| 579 | Phosphorylation | GEGKSETSAKSSPEL CCCCCCCCCCCCCCH | 49.65 | 22817900 | |
| 582 | Phosphorylation | KSETSAKSSPELNKQ CCCCCCCCCCCHHCC | 59.80 | 22817900 | |
| 583 | Phosphorylation | SETSAKSSPELNKQP CCCCCCCCCCHHCCC | 45.58 | 22817900 | |
| 624 | Phosphorylation | SEDQALLMLSDDEEA CHHHEEEECCCHHHH | 29.64 | 18327897 | |
| 627 | Phosphorylation | QALLMLSDDEEANAM HEEEECCCHHHHHHH | 51.33 | 18327897 | |
| 628 | Phosphorylation | ALLMLSDDEEANAMM EEEECCCHHHHHHHH | 22.99 | 18327897 | |
| 673 | Phosphorylation | GSGGRQLSLLEMLDT CCCCHHHHHHHHHHH | 52.86 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PARG_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PARG_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PARG_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CADE_DROME | shg | genetic | 22453833 | |
| PARP_DROME | Parp | genetic | 16219773 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-73; SER-624;SER-627 AND SER-628, AND MASS SPECTROMETRY. | |
