PAQR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAQR3_HUMAN
• UniProt AC: Q6TCH7
• Protein Name: Progestin and adipoQ receptor family member 3 {ECO:0000303|PubMed:16044242}
• Gene Name: PAQR3 {ECO:0000312|HGNC:HGNC:30130}
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi..
• Protein Sequence: MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPGSLKDNPYITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLAMILAVFFAQIHPNYLTQQWQRLRSIIFCSVSGYGVIPTLHWVWLNGGIGAPIVQDFAPRVIVMYMIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHILAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MHQKLLKSAHY ----CCHHHHHHCCE	40.90	-
8	Phosphorylation	MHQKLLKSAHYIELG CCHHHHHHCCEEECC	21.90	27642862
11	Phosphorylation	KLLKSAHYIELGSYQ HHHHHCCEEECCCCC	8.87	27642862
16	Phosphorylation	AHYIELGSYQYWPVL CCEEECCCCCEEEEE	22.99	-
17	Phosphorylation	HYIELGSYQYWPVLV CEEECCCCCEEEEEE	12.11	25884760
19	Phosphorylation	IELGSYQYWPVLVPR EECCCCCEEEEEEEC	11.93	22817900
31	Phosphorylation	VPRGIRLYTYEQIPG EECCEEEEEEECCCC	9.45	27642862
32	Phosphorylation	PRGIRLYTYEQIPGS ECCEEEEEEECCCCC	25.77	-
33	Phosphorylation	RGIRLYTYEQIPGSL CCEEEEEEECCCCCC	7.71	22817900
33	Nitration	RGIRLYTYEQIPGSL CCEEEEEEECCCCCC	7.71	-
41 (in isoform 4)	Ubiquitination	-	58.10	21906983
41 (in isoform 3)	Ubiquitination	-	58.10	21906983
41 (in isoform 1)	Ubiquitination	-	58.10	21906983
41 (in isoform 2)	Ubiquitination	-	58.10	21906983
41	Ubiquitination	EQIPGSLKDNPYITD ECCCCCCCCCCCCCC	58.10	22817900
45	Phosphorylation	GSLKDNPYITDGYRA CCCCCCCCCCCHHHH	23.78	22817900
50	Phosphorylation	NPYITDGYRAYLPSR CCCCCCHHHHHCCHH	8.55	22817900
101	Phosphorylation	VLPSASASREDFVIC CCCCCCCCCHHHHHH	33.44	25106551
244 (in isoform 3)	Phosphorylation	-	3.72	22210691
256 (in isoform 3)	Phosphorylation	-	19.07	22210691
266 (in isoform 3)	Phosphorylation	-	27.12	22210691
302	Ubiquitination	VMQYRHSKPCPDYVS HHHCCCCCCCCCHHC	44.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
32	T	Phosphorylation	Kinase	PRKAA1	Q13131	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAQR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAQR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDB2_HUMAN	DDB2	physical	26205499
TWST1_HUMAN	TWIST1	physical	26905590
FBW1A_HUMAN	BTRC	physical	26905590
NF2L2_HUMAN	NFE2L2	physical	27212020
KEAP1_HUMAN	KEAP1	physical	27212020
RD23B_HUMAN	RAD23B	physical	28473198

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.