PAPOB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAPOB_HUMAN
• UniProt AC: Q9NRJ5
• Protein Name: Poly(A) polymerase beta
• Gene Name: PAPOLB
• Organism: Homo sapiens (Human).
• Sequence Length: 636
• Subcellular Localization: Nucleus .
• Protein Sequence: MPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQRRILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPSHVDRSDFFTSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWSKLFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEMGMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDLSAGCENSMSVPSSTSTMKTGPLISSSQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAVSQPAISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	NVGGKIFTFGSYRLG CCCCEEEEECCEECC	30.47	20068231
102	Phosphorylation	GKIFTFGSYRLGVHT CEEEEECCEECCCCC	11.68	20068231
103	Phosphorylation	KIFTFGSYRLGVHTK EEEEECCEECCCCCC	15.38	20068231
109	Phosphorylation	SYRLGVHTKGADIDA CEECCCCCCCCCCCE	28.85	24719451
110	Phosphorylation	YRLGVHTKGADIDAL EECCCCCCCCCCCEE	36.90	24719451
139	Ubiquitination	SFYAKLKLQEEVKDL HHHHHHHHHHHHHHH	12.88	-
144	Acetylation	LKLQEEVKDLRAVEE HHHHHHHHHHHHHHH	55.09	178226425
144	Ubiquitination	LKLQEEVKDLRAVEE HHHHHHHHHHHHHHH	55.09	-
145	Acetylation	KLQEEVKDLRAVEEA HHHHHHHHHHHHHHH	46.71	-
145	Ubiquitination	KLQEEVKDLRAVEEA HHHHHHHHHHHHHHH	46.71	21906983
188	Phosphorylation	DLDLRDDSLLKNLDI CCCCCCCHHHHCCCH	39.63	24719451
191	Ubiquitination	LRDDSLLKNLDIRCI CCCCHHHHCCCHHHH	61.84	-
192	Ubiquitination	RDDSLLKNLDIRCIR CCCHHHHCCCHHHHH	42.80	21906983
307	Phosphorylation	WDPRVNPSDRYHLMP CCCCCCHHHCCCCCE	29.53	24275569
310	Phosphorylation	RVNPSDRYHLMPIIT CCCHHHCCCCCEEEC	12.33	23403867
311	Phosphorylation	VNPSDRYHLMPIITP CCHHHCCCCCEEECC	19.28	-
317	Phosphorylation	YHLMPIITPAYPQQN CCCCEEECCCCCCCC	11.55	23403867
325	Phosphorylation	PAYPQQNSTYNVSIS CCCCCCCCCCCEEEE	28.12	23403867
326	Phosphorylation	AYPQQNSTYNVSIST CCCCCCCCCCEEEEC	27.02	23403867
327	Phosphorylation	YPQQNSTYNVSISTR CCCCCCCCCEEEECC	17.25	23403867
330	Phosphorylation	QNSTYNVSISTRMVM CCCCCCEEEECCEEE	13.74	23403867
332	Phosphorylation	STYNVSISTRMVMIE CCCCEEEECCEEEHH	11.49	24275569
333	Phosphorylation	TYNVSISTRMVMIEE CCCEEEECCEEEHHH	22.55	24275569
371	Phosphorylation	APSFFQKYKHYIVLL CCHHHHHCCHHHEEE	7.69	25332170
380	Phosphorylation	HYIVLLASASTEKQH HHHEEEEECCCCHHH	23.79	25332170
484	Phosphorylation	FEMGMKITAMHLRRK HHHHHHHHHHHHHHH	16.65	-
526	Phosphorylation	NDSSFDLSAGCENSM CCCCCCCCCCCCCCC	25.18	-
605	Phosphorylation	SQPAISPSPKAMVAR CCCCCCCCCHHHHHH	32.04	15302935

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAPOB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAPOB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAPOB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC38_HUMAN	TTC38	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.