PABP8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PABP8_ARATH
• UniProt AC: Q9FXA2
• Protein Name: Polyadenylate-binding protein 8
• Gene Name: PAB8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 671
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation (By similarity). During infection with potyvirus TuMV, acts as a potential integral component of the viral replicase complex that could play an important role in the regulation of potyviral RNA-dependent RNA polymerase (RdRp) (By similarity)..
• Protein Sequence: MAQIQHQGQNANGGVAVPGAAAAEAAAAAAGAAAAAAGAAQQGTTSLYVGDLDATVTDSQLFEAFTQAGQVVSVRVCRDMTTRRSLGYGYVNYATPQDASRALNELNFMALNGRAIRVMYSVRDPSLRKSGVGNIFIKNLDKSIDHKALHETFSAFGPILSCKVAVDPSGQSKGYGFVQYDTDEAAQGAIDKLNGMLLNDKQVYVGPFVHKLQRDPSGEKVKFTNVYVKNLSESLSDEELNKVFGEFGVTTSCVIMRDGEGKSKGFGFVNFENSDDAARAVDALNGKTFDDKEWFVGKAQKKSERETELKQKFEQSLKEAADKSQGSNLYVKNLDESVTDDKLREHFAPFGTITSCKVMRDPSGVSRGSGFVAFSTPEEATRAITEMNGKMIVTKPLYVALAQRKEDRKARLQAQFSQMRPVNMPPAVGPRMQMYPPGGPPMGQQLFYGQGPPAMIPQPGFGYQQQLVPGMRPGGSPMPNFFMPMMQQGQQQQQQQQQQQRPGGGRRGALPQPQQPSPMMQQQMHPRGRMYRYPQRDVNTMPGPTQNMLSVPYDVSSGGGVHHRDSPTSQPVPIVALATRLANAAPEQQRTMLGENLYPLVEQLEPESAAKVTGMLLEMDQTEVLHLLESPEALKAKVTEAMDVLRSVAQQQAGGAADQLASLSLGDNIVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	VRVCRDMTTRRSLGY EEEECCCCCCCCCCC		19880383
196	Sulfoxidation	AIDKLNGMLLNDKQV HHHHHCCEECCCCEE		25693801
236	Phosphorylation	KNLSESLSDEELNKV EEHHHHCCHHHHHHH		19880383
337	Phosphorylation	YVKNLDESVTDDKLR EEECCCCCCCCHHHH		19880383
369	Phosphorylation	PSGVSRGSGFVAFST CCCCCCCCCEEEECC		19880383
556	Phosphorylation	LSVPYDVSSGGGVHH EECCEEECCCCCCCC		29654922
557	Phosphorylation	SVPYDVSSGGGVHHR ECCEEECCCCCCCCC		29654922
566	Phosphorylation	GGVHHRDSPTSQPVP CCCCCCCCCCCCCCC		23111157
568	Phosphorylation	VHHRDSPTSQPVPIV CCCCCCCCCCCCCHH		19880383
569	Phosphorylation	HHRDSPTSQPVPIVA CCCCCCCCCCCCHHH		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PABP8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PABP8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PABP8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CID2_ARATH	AT4G14270	physical	21798944
CID4_ARATH	CID4	physical	21798944
ERD15_ARATH	ERD15	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.