PABP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PABP2_ARATH
• UniProt AC: P42731
• Protein Name: Polyadenylate-binding protein 2
• Gene Name: PAB2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 629
• Subcellular Localization: Cytoplasm . Nucleus . In TuMV-infected plants, partially retargeted in cytoplasmic virus-induced vesicles and in the nucleolus.
• Protein Description: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the cytoplasm, affects both translation and mRNA decay. Stimulates translation by interaction with translation initiation factor eIF4G, a subunit of the cap-binding complex eIF4F, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. During infection with potyvirus TuMV, acts as a potential integral component of the viral replicase complex that could play an important role in the regulation of potyviral RNA-dependent RNA polymerase (RdRp)..
• Protein Sequence: MAQVQLQGQTPNGSTAAVTSAPATSGGATATQFGNTSLYVGDLDFNVTDSQLFDAFGQMGTVVTVRVCRDLVTRRSLGYGYVNFTNPQDAARAIQELNYIPLYGKPIRVMYSHRDPSVRRSGAGNIFIKNLDESIDHKALHDTFSSFGNIVSCKVAVDSSGQSKGYGFVQYANEESAQKAIEKLNGMLLNDKQVYVGPFLRRQERDSTANKTKFTNVYVKNLAESTTDDDLKNAFGEYGKITSAVVMKDGEGKSKGFGFVNFENADDAARAVESLNGHKFDDKEWYVGRAQKKSERETELRVRYEQNLKEAADKFQSSNLYVKNLDPSISDEKLKEIFSPFGTVTSSKVMRDPNGTSKGSGFVAFATPEEATEAMSQLSGKMIESKPLYVAIAQRKEDRRVRLQAQFSQVRPVAMQPSVGPRMPVYPPGGPGIGQQMFYGQAPPAMIPPQPGYGYQQQLVPGMRPGGGPVPSFFMPMVQPQQQRPGGGRRPGGIQHSQQQNPMMQQQMHPRGRMFRYPQGRGGSGDVPPYDMGNNMPLTIGALASNLSNATPEQQRTMLGEVLYPLVEQVEAESAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAMDVLRSVAAGGATEQLASLNLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
247	Sulfoxidation	KITSAVVMKDGEGKS EEEEEEEEECCCCCC	2.35	25693801
350	Sulfoxidation	TVTSSKVMRDPNGTS CEECCCEEECCCCCC	4.64	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PABP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PABP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PABP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERD15_ARATH	ERD15	physical	18796636
CID7_ARATH	CID7	physical	18796636
CID8_ARATH	CID8	physical	18796636
CID12_ARATH	CID12	physical	18796636
LRP6B_ARATH	AT2G43970	physical	23148093
LRP6C_ARATH	AT3G19090	physical	23148093
ERD15_ARATH	ERD15	physical	15650869
CID7_ARATH	CID7	physical	15650869

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.