OTUD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTUD3_HUMAN
• UniProt AC: Q5T2D3
• Protein Name: OTU domain-containing protein 3
• Gene Name: OTUD3
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Protein Description: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains..
• Protein Sequence: MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTEKSSVRELHIAYRYGEHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGMDSEDDLRDEVEDAVQKVCNATGCSDFNLIVQNLEAENYNIESAIIAVLRMNQGKRNNAEENLEPSGRVLKQCGPLWEEGGSGARIFGNQGLNEGRTENNKAQASPSEENKANKNQLAKVTNKQRREQQWMEKKKRQEERHRHKALESRGSHRDNNRSEAEANTQVTLVKTFAALNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Trimethylation	RKAEAERKRDERAAR HHHHHHHHHHHHHHH	56.56	-
23	Methylation	RKAEAERKRDERAAR HHHHHHHHHHHHHHH	56.56	-
43	Phosphorylation	ERRNRPESGGGGGCE HHHCCCCCCCCCCCH	45.48	29802988
55	Phosphorylation	GCEEEFVSFANQLQA CCHHHHHHHHHHHHH	24.78	-
105	Ubiquitination	ETVDYMIKQREDFEP HHHHHHHHCCCCCCC	27.11	29967540
122	Ubiquitination	EDDIPFEKHVASLAK CCCCCHHHHHHHHCC	43.70	29967540
179	Phosphorylation	ELHIAYRYGEHYDSV HHHHHHHHHCCHHHC	17.75	29449344
185	Phosphorylation	RYGEHYDSVRRINDN HHHCCHHHCEECCCC	15.45	22210691
224	Phosphorylation	IKTKGMDSEDDLRDE HHHCCCCCHHHHHHH	33.75	30266825
326	Phosphorylation	ENNKAQASPSEENKA CCCCCCCCCCHHHHH	19.51	29214152
328	Phosphorylation	NKAQASPSEENKANK CCCCCCCCHHHHHCH	55.86	28985074
340	Ubiquitination	ANKNQLAKVTNKQRR HCHHHHHHHHHHHHH	59.18	30230243
342	Phosphorylation	KNQLAKVTNKQRREQ HHHHHHHHHHHHHHH	35.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTUD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTUD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTUD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	23827681
PTEN_HUMAN	PTEN	physical	26280536
OTUD3_HUMAN	OTUD3	physical	26280536
UBC_HUMAN	UBC	physical	27066941

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224, AND MASSSPECTROMETRY.
PubMed: 18669648