OSTP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OSTP_RAT
• UniProt AC: P08721
• Protein Name: Osteopontin
• Gene Name: Spp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 317
• Subcellular Localization: Secreted.
• Protein Description: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.; Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity..
• Protein Sequence: MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWLKPDPSQKQNLLAPQNSVSSEETDDFKQETLPSNSNESHDHMDDDDDDDDDGDHAESEDSVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDVPDGRGDSLAYGLRSKSRSFPVSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSHESSQLDEPSVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEHQSHEFHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VKVAEFGSSEEKAHY HHHHHCCCHHHHHHH	39.64	18779572
27	Phosphorylation	KVAEFGSSEEKAHYS HHHHCCCHHHHHHHC	50.59	22673903
37	Phosphorylation	KAHYSKHSDAVATWL HHHHCCCCCHHHHHC	30.88	25532521
60	Phosphorylation	NLLAPQNSVSSEETD CCCCCCCCCCCCCCC	20.37	24972320
62	Phosphorylation	LAPQNSVSSEETDDF CCCCCCCCCCCCCCC	31.67	25532521
63	Phosphorylation	APQNSVSSEETDDFK CCCCCCCCCCCCCCH	36.98	25532521
66	Phosphorylation	NSVSSEETDDFKQET CCCCCCCCCCCHHHC	36.50	15865444
76	Phosphorylation	FKQETLPSNSNESHD CHHHCCCCCCCCCCC	56.88	-
78	Phosphorylation	QETLPSNSNESHDHM HHCCCCCCCCCCCCC	46.44	15865444
81	Phosphorylation	LPSNSNESHDHMDDD CCCCCCCCCCCCCCC	38.17	15865444
106	Phosphorylation	ESEDSVNSDESDESH CCCCCCCCCCCCCCC	40.37	-
109	Phosphorylation	DSVNSDESDESHHSD CCCCCCCCCCCCCCC	52.23	-
112	Phosphorylation	NSDESDESHHSDESD CCCCCCCCCCCCCCC	31.33	-
115	Phosphorylation	ESDESHHSDESDESF CCCCCCCCCCCCCCC	37.34	-
118	Phosphorylation	ESHHSDESDESFTAS CCCCCCCCCCCCCHH	52.23	-
121	O-linked_Glycosylation	HSDESDESFTASTQA CCCCCCCCCCHHHHC	32.65	OGP
123	O-linked_Glycosylation	DESDESFTASTQADV CCCCCCCCHHHHCCE	29.04	-
132	O-linked_Glycosylation	STQADVLTPIAPTVD HHHCCEECCCCCCCC	16.70	-
137	O-linked_Glycosylation	VLTPIAPTVDVPDGR EECCCCCCCCCCCCC	21.95	-
147	Phosphorylation	VPDGRGDSLAYGLRS CCCCCCCCHHHHHHC	20.09	25532521
162	Phosphorylation	KSRSFPVSDEQYPDA CCCCCCCCCCCCCCC	35.35	25532521
166	Phosphorylation	FPVSDEQYPDATDED CCCCCCCCCCCCCHH	10.88	25532521
170	Phosphorylation	DEQYPDATDEDLTSR CCCCCCCCCHHHHHH	47.50	24972320
175	Phosphorylation	DATDEDLTSRMKSQE CCCCHHHHHHHHHCC	26.97	-
176	Phosphorylation	ATDEDLTSRMKSQES CCCHHHHHHHHHCCC	37.36	15865444
180	Phosphorylation	DLTSRMKSQESDEAI HHHHHHHHCCCHHHH	29.82	25532521
183	Phosphorylation	SRMKSQESDEAIKVI HHHHHCCCHHHHCCE	32.87	25532521
200	Phosphorylation	AQRLSVPSDQDSNGK HHHCCCCCCCCCCCC	45.83	-
204	Phosphorylation	SVPSDQDSNGKTSHE CCCCCCCCCCCCCCC	41.68	18779572
208	Phosphorylation	DQDSNGKTSHESSQL CCCCCCCCCCCCHHC	36.39	16641100
209	Phosphorylation	QDSNGKTSHESSQLD CCCCCCCCCCCHHCC	28.83	16641100
212	Phosphorylation	NGKTSHESSQLDEPS CCCCCCCCHHCCCCC	20.26	16641100
213	Phosphorylation	GKTSHESSQLDEPSV CCCCCCCHHCCCCCC	31.60	25532521
219	Phosphorylation	SSQLDEPSVETHSLE CHHCCCCCCCCCCHH	30.45	15865444
222	Phosphorylation	LDEPSVETHSLEQSK CCCCCCCCCCHHHHH	18.01	16641100
224	Phosphorylation	EPSVETHSLEQSKEY CCCCCCCCHHHHHHH	40.81	25532521
228	Phosphorylation	ETHSLEQSKEYKQRA CCCCHHHHHHHHHHH	20.34	-
236	Phosphorylation	KEYKQRASHESTEQS HHHHHHHCCCCCHHH	29.94	25532521
243	Phosphorylation	SHESTEQSDAIDSAE CCCCCHHHHHHCCCC	23.83	30181290
248	Phosphorylation	EQSDAIDSAEKPDAI HHHHHHCCCCCCCCC	32.01	25532521
257	Phosphorylation	EKPDAIDSAERSDAI CCCCCCCHHHHHHHH	26.39	25532521
261	Phosphorylation	AIDSAERSDAIDSQA CCCHHHHHHHHCHHH	23.93	15865444
266	Phosphorylation	ERSDAIDSQASSKAS HHHHHHCHHHHHHHH	22.87	-
270	Phosphorylation	AIDSQASSKASLEHQ HHCHHHHHHHHHHHH	34.94	-
273	Phosphorylation	SQASSKASLEHQSHE HHHHHHHHHHHHCCC	37.72	15865444
278	Phosphorylation	KASLEHQSHEFHSHE HHHHHHHCCCCCCCC	27.22	24972320
283	Phosphorylation	HQSHEFHSHEDKLVL HHCCCCCCCCCCEEE	33.61	25532521
294	Phosphorylation	KLVLDPKSKEDDRYL CEEECCCCCCCCHHH	46.82	15865444
306	Phosphorylation	RYLKFRISHELESSS HHHHHHHHHHHHCCC	13.47	27097102
311	Phosphorylation	RISHELESSSSEVN- HHHHHHHCCCCCCC-	48.41	27097102
312	Phosphorylation	ISHELESSSSEVN-- HHHHHHCCCCCCC--	28.62	27097102
313	Phosphorylation	SHELESSSSEVN--- HHHHHCCCCCCC---	39.53	27097102
314	Phosphorylation	HELESSSSEVN---- HHHHCCCCCCC----	47.73	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OSTP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OSTP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OSTP_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAP1A_RAT	Map1a	physical	22779921
MAP1B_RAT	Map1b	physical	22779921
IFM3_HUMAN	IFITM3	physical	19901966
IFM3_RAT	Ifitm3	physical	19901966

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.