dbPTM

IFM3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IFM3_RAT
UniProt AC	P26376
Protein Name	Interferon-induced transmembrane protein 3
Gene Name	ifitm3
Organism	Rattus norvegicus (Rat).
Sequence Length	137
Subcellular Localization	Cell membrane Single-pass type II membrane protein. Late endosome membrane Single-pass type II membrane protein. Lysosome membrane Single-pass type II membrane protein.
Protein Description	May inhibit early replication of influenza A virus, dengue virus, and West Nile virus..
Protein Sequence	MNHTSQAFVNAATGGQPPNYERIKEEYEVSELGAPHGSASVRTTVINMPREVSVPDHVVWSLFNTLFMNFCCLGFIAYAYSVKSRDRKMVGDMTGAQAYASTAKCLNISSLVLSILMVIITIVTVVIIALNAPRLQT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	TGGQPPNYERIKEEY CCCCCCCHHHHHHHH	16.62	30181290
27	Phosphorylation	YERIKEEYEVSELGA HHHHHHHHHHHHCCC	23.79	22817900
30	Phosphorylation	IKEEYEVSELGAPHG HHHHHHHHHCCCCCC	18.37	21630457
38	Phosphorylation	ELGAPHGSASVRTTV HCCCCCCCCCCEEEE	17.84	23984901
40	Phosphorylation	GAPHGSASVRTTVIN CCCCCCCCCEEEEEC	17.52	22673903
71	S-palmitoylation	NTLFMNFCCLGFIAY HHHHHHHHHHHHHHH	1.27	-
72	S-palmitoylation	TLFMNFCCLGFIAYA HHHHHHHHHHHHHHH	3.49	-
105	S-palmitoylation	AYASTAKCLNISSLV HHHHHHHHHCHHHHH	3.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IFM3_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
24	K	ubiquitylation	-
Lys-24 is the most prevalent ubiquitination site (By similarity).
48	K	ubiquitylation	-
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages.
63	K	ubiquitylation	-
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IFM3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IFM3_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IFM3_RAT

Related Literatures of Post-Translational Modification