OSTA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OSTA_HUMAN
• UniProt AC: Q86UW1
• Protein Name: Organic solute transporter subunit alpha
• Gene Name: SLC51A
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral
• Protein Description: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids..
• Protein Sequence: MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLLALGSIAIFLEDAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGGKEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPADISEGSTALWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	O-linked_Glycosylation	IKLDPRYTADLLEVL EECCCCCHHHHHHHH	18.25	29237092
38	O-linked_Glycosylation	ACFSQPPTAAQLLRA HHHCCCCHHHHHHHH	41.11	29237092
193	Phosphorylation	QYAFLKITLTLVGLF HHHHHHHHHHHHHHH	16.47	-
195	Phosphorylation	AFLKITLTLVGLFLV HHHHHHHHHHHHHCC	15.67	-
240	Phosphorylation	LWTLGIISRQARLHL HHHHHHHHHHHHHHC	19.20	-
330	Phosphorylation	KVGYETFSSPDLDLN CCCCCCCCCCCCCCC	48.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OSTA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OSTA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OSTA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANO6_HUMAN	ANO6	physical	28514442
CSCL1_HUMAN	TMEM63A	physical	28514442
UBB_HUMAN	UBB	physical	28514442
FA8A1_HUMAN	FAM8A1	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.