OLR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OLR1_HUMAN
• UniProt AC: P78380
• Protein Name: Oxidized low-density lipoprotein receptor 1
• Gene Name: OLR1
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. A secreted form also exists. Localization to membrane rafts requires palmitoylation.
• Protein Description: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria..
• Protein Sequence: MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MTFDDLKIQTVKDQ -CCCCCCCEEECCCC	39.50	-
10	Phosphorylation	FDDLKIQTVKDQPDE CCCCCEEECCCCCCC	32.75	26074081
12	Ubiquitination	DLKIQTVKDQPDEKS CCCEEECCCCCCCCC	54.77	-
19	Phosphorylation	KDQPDEKSNGKKAKG CCCCCCCCCCCCCCC	49.09	25159151
36	S-palmitoylation	FLYSPWWCLAAATLG HHHCHHHHHHHHHHH	1.31	23583401
46	S-palmitoylation	AATLGVLCLGLVVTI HHHHHHHHHHHHHHH	2.35	23583401
61	Phosphorylation	MVLGMQLSQVSDLLT HHHHHCHHHHHHHHH	16.19	27174698
64	Phosphorylation	GMQLSQVSDLLTQEQ HHCHHHHHHHHHHHH	18.20	27174698
68	Phosphorylation	SQVSDLLTQEQANLT HHHHHHHHHHHHHCH	37.04	27174698
73	N-linked_Glycosylation	LLTQEQANLTHQKKK HHHHHHHHCHHHHHH	45.20	UniProtKB CARBOHYD
75	Phosphorylation	TQEQANLTHQKKKLE HHHHHHCHHHHHHHH	23.28	27174698
80	Ubiquitination	NLTHQKKKLEGQISA HCHHHHHHHHHHHHH	59.82	-
95	Phosphorylation	RQQAEEASQESENEL HHHHHHHHHHCHHHH	37.45	28355574
98	Phosphorylation	AEEASQESENELKEM HHHHHHHCHHHHHHH	37.78	-
112	Ubiquitination	MIETLARKLNEKSKE HHHHHHHHHHHHHHH	50.48	-
118	Ubiquitination	RKLNEKSKEQMELHH HHHHHHHHHHHHHHH	64.13	-
139	N-linked_Glycosylation	ETLKRVANCSAPCPQ HHHHHHHCCCCCCCC	19.88	22688517
171	Ubiquitination	NWEKSQEKCLSLDAK CCHHHHHHHHHCCCH	32.60	-
178	Ubiquitination	KCLSLDAKLLKINST HHHHCCCHHHHCCCC	54.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OLR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OLR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OLR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FA5_HUMAN	F5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.