OARD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OARD1_HUMAN
• UniProt AC: Q9Y530
• Protein Name: O-acetyl-ADP-ribose deacetylase 1
• Gene Name: OARD1
• Organism: Homo sapiens (Human).
• Sequence Length: 152
• Protein Description: Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively..
• Protein Sequence: MASSLNEDPEGSRITYVKGDLFACPKTDSLAHCISEDCRMGAGIAVLFKKKFGGVQELLNQQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEAMKSHCLKNGVTDLSMPRIGCGLDRLQWENVSAMIEEVFEATDIKITVYTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSLNEDP ------CCCCCCCCC		22223895
3	Phosphorylation	-----MASSLNEDPE -----CCCCCCCCCC		23401153
4	Phosphorylation	----MASSLNEDPEG ----CCCCCCCCCCC		25159151
12	Phosphorylation	LNEDPEGSRITYVKG CCCCCCCCCEEEEEC		22199227
15	Phosphorylation	DPEGSRITYVKGDLF CCCCCCEEEEECCEE		23186163
18	Acetylation	GSRITYVKGDLFACP CCCEEEEECCEEECC		26051181
18	Ubiquitination	GSRITYVKGDLFACP CCCEEEEECCEEECC		-
26	Acetylation	GDLFACPKTDSLAHC CCEEECCCCCCHHHH		26051181
26	Ubiquitination	GDLFACPKTDSLAHC CCEEECCCCCCHHHH		-
50	Acetylation	GIAVLFKKKFGGVQE CEEEEEHHHHCCHHH		25953088
51	Acetylation	IAVLFKKKFGGVQEL EEEEEHHHHCCHHHH		25953088
51	Malonylation	IAVLFKKKFGGVQEL EEEEEHHHHCCHHHH		26320211
51	Ubiquitination	IAVLFKKKFGGVQEL EEEEEHHHHCCHHHH		-
63	Ubiquitination	QELLNQQKKSGEVAV HHHHHHHCCCCCEEE		-
64	Ubiquitination	ELLNQQKKSGEVAVL HHHHHHCCCCCEEEE		-
72	Ubiquitination	SGEVAVLKRDGRYIY CCCEEEEEECCCEEE		-
72	Acetylation	SGEVAVLKRDGRYIY CCCEEEEEECCCEEE		25953088
79	Phosphorylation	KRDGRYIYYLITKKR EECCCEEEEEEECCC		21406692
80	Phosphorylation	RDGRYIYYLITKKRA ECCCEEEEEEECCCC		21406692
83	Phosphorylation	RYIYYLITKKRASHK CEEEEEEECCCCCCC		21406692
84	Acetylation	YIYYLITKKRASHKP EEEEEEECCCCCCCC		25953088
90	Ubiquitination	TKKRASHKPTYENLQ ECCCCCCCCCHHHHH		-
92	Phosphorylation	KRASHKPTYENLQKS CCCCCCCCHHHHHHH		29496907
93	Phosphorylation	RASHKPTYENLQKSL CCCCCCCHHHHHHHH		27642862
98	Ubiquitination	PTYENLQKSLEAMKS CCHHHHHHHHHHHHH		-
104	Ubiquitination	QKSLEAMKSHCLKNG HHHHHHHHHHHHHCC		-
109	Ubiquitination	AMKSHCLKNGVTDLS HHHHHHHHCCCCCCC		-
109	Acetylation	AMKSHCLKNGVTDLS HHHHHHHHCCCCCCC		25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OARD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OARD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OARD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
OXSR1_HUMAN	OXSR1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.