NUMBL_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUMBL_RAT
• UniProt AC: A1L1I3
• Protein Name: Numb-like protein
• Gene Name: Numbl
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 614
• Subcellular Localization: Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS..
• Protein Description: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons (By similarity)..
• Protein Sequence: MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
224	Phosphorylation	TSFAREGSFRLSGGG CCCCCCCCEECCCCC	11.48	-
228	Phosphorylation	REGSFRLSGGGRPAE CCCCEECCCCCCCCC	31.00	-
263	Phosphorylation	PAQPGHVSPTPATTS CCCCCCCCCCCCCCC	19.85	30411139
265	Phosphorylation	QPGHVSPTPATTSPG CCCCCCCCCCCCCCC	20.32	27097102
268	Phosphorylation	HVSPTPATTSPGEKG CCCCCCCCCCCCCCC	29.07	27097102
269	Phosphorylation	VSPTPATTSPGEKGE CCCCCCCCCCCCCCC	34.72	27097102
270	Phosphorylation	SPTPATTSPGEKGEA CCCCCCCCCCCCCCC	26.93	30411139
279	Phosphorylation	GEKGEAGTPVAAGTT CCCCCCCCCCCCCCC	22.95	-
285	Phosphorylation	GTPVAAGTTAAAIPR CCCCCCCCCCCCCCC	14.45	30240740
305	Phosphorylation	EQLVRQGSFRGFPAL HHHHHCCCCCCCHHH	11.93	25575281
313	Phosphorylation	FRGFPALSQKNSPFK CCCCHHHCCCCCHHH	41.01	25575281
324	Phosphorylation	SPFKRQLSLRLNELP CHHHHHHHHHHHHCC	11.78	25532521
409	Phosphorylation	FQPGHKRTPSEAERW CCCCCCCCHHHHHHH	35.65	28432305
411	Phosphorylation	PGHKRTPSEAERWLE CCCCCCHHHHHHHHH	49.15	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
305	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUMBL_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUMBL_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AUP1_RAT	Aup1	physical	18299187

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.