AUP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AUP1_RAT
• UniProt AC: A1L134
• Protein Name: Ancient ubiquitous protein 1
• Gene Name: Aup1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 410
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.
• Protein Description: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome..
• Protein Sequence: MEPPPAPGPERLFDSHRLPSDGFLLLALLLYAPVGLCLLVLRLFLGLHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMDRRVELVESLKKFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLHPIRRQLGEENEEFALRVQQLVAKELGQIGTRLTPADKAEHMKRQRHPRLRPQSVQSSFPSPPSPSSDVQLTILAQRVKEVLPHVPLNVIQRDLARTGCVDLTITNLLEGAVAFMPEDVTEGSQSLPTASAPKFPSSGLVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFRERQAQEAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPPPAPG -------CCCCCCCC	18.41	-
250	Ubiquitination	RVQQLVAKELGQIGT HHHHHHHHHHHCCCC	46.09	-
280	Phosphorylation	HPRLRPQSVQSSFPS CCCCCCCHHHHCCCC	25.47	23984901
283	Phosphorylation	LRPQSVQSSFPSPPS CCCCHHHHCCCCCCC	31.61	23984901
284	Phosphorylation	RPQSVQSSFPSPPSP CCCHHHHCCCCCCCC	24.88	23984901
287	Phosphorylation	SVQSSFPSPPSPSSD HHHHCCCCCCCCCHH	47.64	23984901
290	Phosphorylation	SSFPSPPSPSSDVQL HCCCCCCCCCHHHHH	40.58	22108457
292	Phosphorylation	FPSPPSPSSDVQLTI CCCCCCCCHHHHHHH	43.43	23984901
293	Phosphorylation	PSPPSPSSDVQLTIL CCCCCCCHHHHHHHH	45.22	23984901
298	Phosphorylation	PSSDVQLTILAQRVK CCHHHHHHHHHHHHH	9.24	23984901
363	Phosphorylation	SAPKFPSSGLVTPQP CCCCCCCCCCCCCCC	36.06	-
367	Phosphorylation	FPSSGLVTPQPTALT CCCCCCCCCCCCHHH	22.65	-
385	Phosphorylation	SSWARQESLQERKQA CHHHHHHHHHHHHHH	27.32	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AUP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AUP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AUP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AUP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.