NUDEL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDEL_DROME
• UniProt AC: P98159
• Protein Name: Serine protease nudel
• Gene Name: ndl
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2616
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo..
• Protein Sequence: MNYNMDEMEATRLLRHPRRWWSIGFGKRIVAISILVIIVLLFSLVYHGLVVEKIDQVQQIAALNARHQVLFNQPFEEDQSALIVSPQTLHFKLLDEDMNKDMEDSKNRRRKHMRQMLVKFRLNKKHRMRRDLHGLDLLDPVRMEANMQHLYTKLRSKRAREALSQLEHEFVRCKKHTPQDCMSAFLRMYKMAKEVTEKMEKMKAIMREQQPKLESSSMESHEQKGTFSPADLIQVTTAEATTVAVHATEKPARTKIKPSRISWIIDGHDHDESPVYTDGAPKKETTKAPWNTTQLVEITTTKIDATATERTTVESTTEKISWILDHFDKPQEILRTTEGPGQRIIRNVTTTSASSEPIVDTENTNSDHVPTTENGLVFNITTDGPVETTKSTAQRKLSFDWILDGEENVEPEVKSTNTTTTTAATTTTGATSETIIVTTELPKITFDWIIDGREVVEPQETTTEVTGTTERLRKMPFDWIIDGEEVVEPQENVTTTTIATTVAVSTTEINERIHNSTAYPTKPKPVKFDWIIDGGESSGEVSTSSTSQPKLTTREAISNPESPRSSHPLDNPTSIENMLESFEQHEEQKPILRVLNANESSSETVTDGYERQLWLKKFEDQARPNQNELIDTFGTALDAKALDKMGPKINPLNGHTWNAADAQILSLCERVALRMRNKVATMSDGETKEKGETFTASPSVQFTSRAPGGFPVSGETMKASAQFMFNPNFGMPSIPVCFYMTPANFRMPMWSNTPTFMGMQGAHFGGSSNPGAGIFFVPQQFGPSGNFFGGSGGSGAGGQGANIFSKNASPQKPTNGQQQVYCSYMQNQSGQGAGQSQTSSQQQQGGQSAFSNANFKMRHANQTNTANQQGQIIYASYAGLPQQPIQERSRCPEPDQFSCFGQQECIPAARWCDNVVDCSDGSDESACTCADRVDEERLCDGYEDCPMGEDELGCFGCESLAYSCYENPQDFAKRNRSTISMCYSRLERCDGFMNCLNGRDEEQCSMLVTDVADHMSHGASASEGYLYHNYRGDWHPVCNNGEKWAALACQMDENSRMDHSASLNVSFQTLTLPGPFIEPSLHAGVHFAQACHGRNSHDSLVDHVAYVKCPPMQCGLPSKSSMLEHSKRVRRAVSDSKEIVGDGRIVGGSYTSALQWPFVVAIYRNGKFHCGGTIYSDRWIISAAHCVINYGKYFYEVRAGLLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQFNRWVKPICLPDKGRTTVGDDWIWGPVEHTLCTVVGWGAIREKGPSSDPMRQVIVPIRKKCTDPEDQASEDICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQEFGVYTRVTLYLDWLEMATTPRLLPKLQPLQLCPGFICVWGGKRCIAKRQRCDRNVDCLGGEDEVGCTYNFLPDMVGGVRQNISTTTESDYHPVKESEEKSKMREVIPIDDEDLKAEQDEEDLLKSTTSLGQTETTQGPMDLSFAEQITSTTSDDLSITDETTSTDFTVSDSATSPSTLLPTTTNPSTWLPSTNIETSTFSFTTTESEASTKQETLPTTVAQTTTIPTSTEDLKKLTDLVTEFIESTTFETTMEVETTTLSLTSTDAPKLVTTEGVKETTTTEDTTTISSIVTLTTTPLATISTTILTTEKHVAVTTLAPTTTTESAKTTTTHSSSTHSEKDQIQIPNKFVCKKMSQIVDIMMRCDRKVDCEDGTDELDCTCKDYLKGSLKGLICDGKADCEDLTDEQNCVECQSNEFRCPLSKTCLPLSSRCDNKVDCKFKEDEKDCFALTNGHDVHFDVHQQPKFSSTGIFSRNGHGVWRVVCAHETGYHEHQAKTADAVCALLGFNGAHYFNSSEFVTQHEMQPITPELKGGRNRMSAQIHSMVGDNVQFTENEVIIPELGHPSASRPEKDRLLPRKCVGIYVECNPYSNKTTPLKTFSAGQVVKEKPIEQVPVLSPTIETHNTPNVHFKPQIPAMVVNKKDEILDRLDKLIKSKKNKTILVNEQLHEAIEELHWPWLADVYMNGDLWCIGVLIDKHWVMVHESCLSGIDLETHYVSVLLGGGKTKRSAHRSNHEQIRRVDCFEGVPKSNVLLLHLERPVRFTHHVLPTFLPDSSHQNQSHARQCISVLHDDATGRIKTVAITRIHNATNCDSCYKLQEKQPPANLMRLLNVSAEDMASISEEVELINGVAPTELPAITKFTTCNQFGLKNVSDAHHNPSDQGVLVCRDSHTGWFPTALFNYNNSDCQSFKQPFGIRTLELVYKSLQDIIDKPSCKMLLPAPDCSTHRCPLGTCLPQAAMCNGRSDCHDGSDEEETKCRQQKQQCAPGEMKCRTSFKCVPKSKFCDHVPDCEDMTDEPTICSCFTYLQATDPSKICDGKRNCWDKSDESSVLCNCTADHFQCSSSPEDCIPRDFVCDKEKDCPNGEDERYCFGIEHPLHLQKKDFWTNSQHTQPEIAPQYGQVIEQTYGIWHTKCFPKSKPPQVDEVREICKKLGYNPYRQPSYRLIDDEENKPVHTYELADRQGRSFSNESLMGKYRDSTKALIISKFSPLQLNERLTLFLKSSRPIAELVRWNATDSSMCYRLEIRCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
215	Phosphorylation	EQQPKLESSSMESHE HHCCCCCCCCCCHHC	37.84	22817900
217	Phosphorylation	QPKLESSSMESHEQK CCCCCCCCCCHHCCC	35.53	22817900
220	Phosphorylation	LESSSMESHEQKGTF CCCCCCCHHCCCCCC	24.55	22817900
291	N-linked_Glycosylation	ETTKAPWNTTQLVEI CCCCCCCCCCEEEEE	31.99	-
347	N-linked_Glycosylation	PGQRIIRNVTTTSAS CCCEEEEECCCCCCC	25.69	-
379	N-linked_Glycosylation	TENGLVFNITTDGPV CCCCEEEEEECCCCC	24.18	-
398	Phosphorylation	STAQRKLSFDWILDG CHHHHEECEEEECCC	24.97	22817900
417	N-linked_Glycosylation	EPEVKSTNTTTTTAA CCCCEECCCCEEEEE	42.38	-
492	N-linked_Glycosylation	EVVEPQENVTTTTIA CCCCCCCCCEECEEE	31.05	-
515	N-linked_Glycosylation	EINERIHNSTAYPTK HHHHHHCCCCCCCCC	38.39	-
574	Phosphorylation	HPLDNPTSIENMLES CCCCCCCHHHHHHHH	29.21	22817900
581	Phosphorylation	SIENMLESFEQHEEQ HHHHHHHHHHHHHHH	30.07	22817900
598	N-linked_Glycosylation	ILRVLNANESSSETV CEEEECCCCCCCCCC	48.92	-
794	O-linked_Glycosylation	FFGGSGGSGAGGQGA CCCCCCCCCCCCCCC	29.06	-
827	N-linked_Glycosylation	VYCSYMQNQSGQGAG EEEEEECCCCCCCCC	22.81	-
829	O-linked_Glycosylation	CSYMQNQSGQGAGQS EEEECCCCCCCCCCC	40.40	-
861	N-linked_Glycosylation	NFKMRHANQTNTANQ HHEEEECCCCCCCCC	42.98	-
975	N-linked_Glycosylation	PQDFAKRNRSTISMC HHHHHHHCHHHHHHH	41.36	-
1064	N-linked_Glycosylation	MDHSASLNVSFQTLT CCCCEEEEEEEEEEE	25.54	-
1134	Phosphorylation	KRVRRAVSDSKEIVG HHHHHHHCCCCCEEC	34.87	18327897
1136	Phosphorylation	VRRAVSDSKEIVGDG HHHHHCCCCCEECCC	25.36	28490779
1445	N-linked_Glycosylation	MVGGVRQNISTTTES HCCCCCCCCCCCCCC	21.44	-
1852	Phosphorylation	RVVCAHETGYHEHQA EEEEECCCCCCHHHH	32.92	22668510
1854	Phosphorylation	VCAHETGYHEHQAKT EEECCCCCCHHHHHH	16.08	22668510
1878	N-linked_Glycosylation	FNGAHYFNSSEFVTQ CCCCCCCCHHHCCCH	37.14	-
1956	N-linked_Glycosylation	VECNPYSNKTTPLKT EEECCCCCCCCCCCE	39.59	-
2023	N-linked_Glycosylation	KLIKSKKNKTILVNE HHHHHCCCCEEEECH	50.90	-
2144	N-linked_Glycosylation	LPDSSHQNQSHARQC CCCCCCCCHHHHHHH	39.64	-
2173	N-linked_Glycosylation	VAITRIHNATNCDSC EEEEEEECCCCCHHH	46.20	-
2197	N-linked_Glycosylation	ANLMRLLNVSAEDMA HHHHHHHCCCHHHHH	30.23	-
2237	N-linked_Glycosylation	CNQFGLKNVSDAHHN CCCCCCCCCHHCCCC	43.50	-
2269	N-linked_Glycosylation	PTALFNYNNSDCQSF CEEEEECCCCCCHHC	42.50	-
2420	N-linked_Glycosylation	DESSVLCNCTADHFQ CCCCEECCCCCCCCC	23.24	-
2556	N-linked_Glycosylation	RQGRSFSNESLMGKY CCCCCCCCHHHHHHC	40.65	-
2601	N-linked_Glycosylation	IAELVRWNATDSSMC HHHHHEECCCCCCCE	23.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDEL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUDEL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDEL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GD_DROME	gd	genetic	10922064

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215; SER-220; SER-574;SER-581; SER-1134 AND SER-1136, AND MASS SPECTROMETRY.
PubMed: 18327897