NTRK3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTRK3_RAT
• UniProt AC: Q03351
• Protein Name: NT-3 growth factor receptor
• Gene Name: Ntrk3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 864
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). NTRK3 isoforms containing insertions within the kinase domain can autophosphorylate in response to NTF3/neurotrophin-3, but cannot mediate downstream phenotypic responses. [PubMed: 8494647]
• Protein Sequence: MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPFSVSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	N-linked_Glycosylation	DSGNSNGNASINITD CCCCCCCCEEEEEEE	34.46	-
72	N-linked_Glycosylation	SNGNASINITDISRN CCCCEEEEEEECCCC	28.72	-
79	N-linked_Glycosylation	NITDISRNITSIHIE EEEECCCCCEEEEEE	34.79	-
133	N-linked_Glycosylation	NPHLRYINLSSNRLT CCCEEEEECCCCCCH	25.57	-
163	N-linked_Glycosylation	RLEQNFFNCSCDIRW HHHHCCCCCCEEEEH	16.80	-
203	N-linked_Glycosylation	QLPLFRMNISQCDLP CCCEEEEEHHHCCCC	26.89	-
218	N-linked_Glycosylation	EISVSHVNLTVREGD CCEEEEEEEEEEECC	25.27	-
232	N-linked_Glycosylation	DNAVITCNGSGSPLP CCEEEEECCCCCCCC	38.73	-
259	N-linked_Glycosylation	NTHQTNLNWTNVHAI CCCCCCCCCEEEEEE	45.67	-
267	N-linked_Glycosylation	WTNVHAINLTLVNVT CEEEEEEEEEEEEEE	27.96	-
272	N-linked_Glycosylation	AINLTLVNVTSEDNG EEEEEEEEEECCCCC	34.17	-
294	N-linked_Glycosylation	ENVVGMSNASVALTV ECCCCCCCCEEEEEE	27.61	-
375	N-linked_Glycosylation	PTHYNNGNYTLIAKN CCCCCCCCEEEEEEC	28.83	-
388	N-linked_Glycosylation	KNALGTANQTINGHF ECCCCCCCCEECCCC	39.09	-
472	Phosphorylation	KGPVAVISGEEDSAS CCCEEEEECCCCCCC	33.29	28432305
477	Phosphorylation	VISGEEDSASPLHHI EEECCCCCCCCCCCC	33.65	28432305
479	Phosphorylation	SGEEDSASPLHHINH ECCCCCCCCCCCCCC	31.76	28432305
489	Phosphorylation	HHINHGITTPSSLDA CCCCCCCCCHHHCCC	36.93	28432305
490	Phosphorylation	HINHGITTPSSLDAG CCCCCCCCHHHCCCC	21.18	28432305
492	Phosphorylation	NHGITTPSSLDAGPD CCCCCCHHHCCCCCC	41.25	28432305
493	Phosphorylation	HGITTPSSLDAGPDT CCCCCHHHCCCCCCE	31.32	28432305
516	Phosphorylation	PVIENPQYFRQGHNC CCCCCHHHHCCCCCC	11.28	N.N.
555 (in isoform 6)	Phosphorylation	-	8.05	-
555 (in isoform 5)	Phosphorylation	-	8.05	-
557 (in isoform 6)	Phosphorylation	-	1.96	-
557 (in isoform 5)	Phosphorylation	-	1.96	-
558	Phosphorylation	KVFLAECYNLSPTKD HEEEEHHHCCCCCCC	15.62	-
561	Phosphorylation	LAECYNLSPTKDKML EEHHHCCCCCCCCCH	27.21	27097102
563	Phosphorylation	ECYNLSPTKDKMLVA HHHCCCCCCCCCHHH	48.80	28432305
705	Phosphorylation	FGMSRDVYSTDYYRE CCCCCCCCCCCCCCC	15.33	22817900
709	Phosphorylation	RDVYSTDYYREGPYQ CCCCCCCCCCCCCCC	12.43	N.N.
710	Phosphorylation	DVYSTDYYREGPYQK CCCCCCCCCCCCCCC	12.66	N.N.
825	Phosphorylation	RVCPKEVYDVMLGCW CCCCHHHHHHHHCCC	12.15	N.N.
859	Phosphorylation	LGKATPIYLDILG-- HHCCCCEEHHCCC--	10.26	N.N.

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTRK3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTRK3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTRK3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR16_RAT	Ngfr	physical	19549834

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.