NTF2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTF2_RAT
• UniProt AC: P61972
• Protein Name: Nuclear transport factor 2 {ECO:0000305}
• Gene Name: Nutf2 {ECO:0000312|RGD:1359213}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 127
• Subcellular Localization: Cytoplasm, cytosol . Nucleus outer membrane . Nucleus, nuclear pore complex . Nucleus inner membrane . Nucleus, nucleoplasm . At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
• Protein Description: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import..
• Protein Sequence: MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MGDKPIWEQIG ----CCCCCHHHHHH	32.45	25786129
55	Acetylation	GKAAIVEKLSSLPFQ CCHHHHHHHHCCCHH	42.65	22902405
55	Ubiquitination	GKAAIVEKLSSLPFQ CCHHHHHHHHCCCHH	42.65	-
79	Phosphorylation	DHQPTPDSCIISMVV CCCCCCCCEEEEEEE	14.39	28689409
80	S-nitrosocysteine	HQPTPDSCIISMVVG CCCCCCCEEEEEEEE	4.11	-
80	S-nitrosylation	HQPTPDSCIISMVVG CCCCCCCEEEEEEEE	4.11	21278135
83	Phosphorylation	TPDSCIISMVVGQLK CCCCEEEEEEEECCC	5.89	25575281
114	S-nitrosocysteine	NINDAWVCTNDMFRL CCCCEEEECHHHHHH	1.73	-
114	S-nitrosylation	NINDAWVCTNDMFRL CCCCEEEECHHHHHH	1.73	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NTF2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTF2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTF2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NTF2_RAT	Nutf2	physical	8757804
RAN_RAT	Ran	physical	8757804
RAN_HUMAN	RAN	physical	10567585
NUP62_MOUSE	Nup62	physical	10543952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.