NT5D3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NT5D3_HUMAN
• UniProt AC: Q86UY8
• Protein Name: 5'-nucleotidase domain-containing protein 3
• Gene Name: NT5DC3
• Organism: Homo sapiens (Human).
• Sequence Length: 548
• Protein Sequence: MTMAAAAVVARGAGARAATAAALRGGCGTAARGRPCAGPARPLCTAPGTAPDMKRYLWERYREAKRSTEELVPSIMSNLLNPDAIFSNNEMSLSDIEIYGFDYDYTLVFYSKHLHTLIFNAARDLLINEHRYPAEIRKYEYDPNFAIRGLHYDVQRAVLMKIDAFHYIQLGTVYRGLSVVPDEEVIEMYEGSHVPLEQMSDFYGKSSHGNTMKQFMDIFSLPEMTLLSCVNEYFLKNNIDYEPVHLYKDVKDSIRDVHIKGIMYRAIEADIEKYICYAEQTRAVLAKLADHGKKMFLITNSPSSFVDKGMSYIVGKDWRDLFDVVIVQAEKPNFFNDKRRPFRKMNEKGVLLWDKIHKLQKGQIYKQGNLYEFLKLTGWRGSRVLYFGDHIYSDLADLTLKHGWRTGAIIPELRSELKIMNTEQYIQTMTWLQTLTGLLEQMQVHRDAESQLVLQEWKKERKEMREMTKSFFNAQFGSLFRTDQNPTYFLRRLSRFADIYMASLSCLLNYDVSHTFYPRRTPLQHELPAWSERPPTFGTPLLQEAQAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	O-linked_Glycosylation	------MTMAAAAVV ------CCHHHHHHH	18.60	30379171
103	Phosphorylation	IEIYGFDYDYTLVFY EEEEEECCCEEEEEE	14.48	22210691
105	Phosphorylation	IYGFDYDYTLVFYSK EEEECCCEEEEEEEC	8.85	22210691
207	Phosphorylation	SDFYGKSSHGNTMKQ HHHCCCCCCCCHHHH	38.61	27251275
248	Acetylation	YEPVHLYKDVKDSIR CCCEECCCCHHHHHH	63.51	23236377
248	Ubiquitination	YEPVHLYKDVKDSIR CCCEECCCCHHHHHH	63.51	19608861
260	Malonylation	SIRDVHIKGIMYRAI HHHHHCCCHHHHHHH	27.75	26320211
274	Phosphorylation	IEADIEKYICYAEQT HHHHHHHHHHHHHHH	5.39	28331001
277	Phosphorylation	DIEKYICYAEQTRAV HHHHHHHHHHHHHHH	12.01	28331001
281	Phosphorylation	YICYAEQTRAVLAKL HHHHHHHHHHHHHHH	16.46	28331001
293	2-Hydroxyisobutyrylation	AKLADHGKKMFLITN HHHHHCCCEEEEEEC	37.33	-
299	Phosphorylation	GKKMFLITNSPSSFV CCEEEEEECCCHHHH	31.61	23403867
301	Phosphorylation	KMFLITNSPSSFVDK EEEEEECCCHHHHHC	19.94	23403867
303	Phosphorylation	FLITNSPSSFVDKGM EEEECCCHHHHHCCC	35.91	23403867
304	Phosphorylation	LITNSPSSFVDKGMS EEECCCHHHHHCCCC	32.45	23403867
312	Phosphorylation	FVDKGMSYIVGKDWR HHHCCCCEEECCCHH	7.25	-
338	Acetylation	KPNFFNDKRRPFRKM CCCCCCCCCCCCHHC	51.95	30590931
355	2-Hydroxyisobutyrylation	KGVLLWDKIHKLQKG CCCEEHHHHHHHHCC	34.82	-
355	Malonylation	KGVLLWDKIHKLQKG CCCEEHHHHHHHHCC	34.82	26320211
365	Phosphorylation	KLQKGQIYKQGNLYE HHHCCCEEECCCHHH	6.86	-
371	Phosphorylation	IYKQGNLYEFLKLTG EEECCCHHHHHHHHC	14.50	28152594
458	Acetylation	QLVLQEWKKERKEMR HHHHHHHHHHHHHHH	43.96	24468199

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NT5D3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NT5D3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NT5D3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NT5D2_HUMAN	NT5DC2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.