NSUN6_HUMAN - dbPTM
NSUN6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NSUN6_HUMAN
UniProt AC Q8TEA1
Protein Name Putative methyltransferase NSUN6
Gene Name NSUN6
Organism Homo sapiens (Human).
Sequence Length 469
Subcellular Localization
Protein Description May have S-adenosyl-L-methionine-dependent methyl-transferase activity..
Protein Sequence MSIFPKISLRPEVENYLKEGFMNKEIVTALGKQEAERKFETLLKHLSHPPSFTTVRVNTHLASVQHVKNLLLDELQKQFNGLSVPILQHPDLQDVLLIPVIGPRKNIKKQQCEAIVGAQCGNAVLRGAHVYAPGIVSASQFMKAGDVISVYSDIKGKCKKGAKEFDGTKVFLGNGISELSRKEIFSGLPELKGMGIRMTEPVYLSPSFDSVLPRYLFLQNLPSALVSHVLNPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLLGLNSIRAFCFDGTKAVKLDMVEDTEGEPPFLPESFDRILLDAPCSGMGQRPNMACTWSVKEVASYQPLQRKLFTAAVQLLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQPQEPQIGGEGMRGAGLSCEQLKQLQRFDPSAVPLPDTDMDSLREARREDMLRLANKDSIGFFIAKFVKCKST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MSIFPKISLRPEV
--CCCCCCCCCCHHH		33.89-
18UbiquitinationPEVENYLKEGFMNKE
HHHHHHHHHCCCCHH		45.4929967540
32UbiquitinationEIVTALGKQEAERKF
HHHHHHCHHHHHHHH		45.9029967540
38AcetylationGKQEAERKFETLLKH
CHHHHHHHHHHHHHH		38.7725953088
38UbiquitinationGKQEAERKFETLLKH
CHHHHHHHHHHHHHH		38.77-
51UbiquitinationKHLSHPPSFTTVRVN
HHCCCCCCCEEEEEC		39.4124816145
68UbiquitinationLASVQHVKNLLLDEL
HHHHHHHHHHHHHHH		39.49-
93UbiquitinationILQHPDLQDVLLIPV
CCCCCCHHHEEEEEE		46.2624816145
109UbiquitinationGPRKNIKKQQCEAIV
CCCCCCCHHHHCHHH		41.63-
133UbiquitinationRGAHVYAPGIVSASQ
CCCEEECCCCCCHHH		18.5030230243
140UbiquitinationPGIVSASQFMKAGDV
CCCCCHHHHHHCCCE		42.0224816145
151PhosphorylationAGDVISVYSDIKGKC
CCCEEEEECCCCCCC		8.2022817900
152PhosphorylationGDVISVYSDIKGKCK
CCEEEEECCCCCCCC		30.6125627689
155UbiquitinationISVYSDIKGKCKKGA
EEEECCCCCCCCCCC		58.2629967540
169UbiquitinationAKEFDGTKVFLGNGI
CCCCCCCEEEECCCH		36.2029967540
180UbiquitinationGNGISELSRKEIFSG
CCCHHHHCHHHHHCC		36.9424816145
182UbiquitinationGISELSRKEIFSGLP
CHHHHCHHHHHCCCH		52.3529967540
186PhosphorylationLSRKEIFSGLPELKG
HCHHHHHCCCHHHCC		45.1129396449
191UbiquitinationIFSGLPELKGMGIRM
HHCCCHHHCCCCCCC		5.6924816145
192UbiquitinationFSGLPELKGMGIRMT
HCCCHHHCCCCCCCC		45.2324816145
199PhosphorylationKGMGIRMTEPVYLSP
CCCCCCCCCCEEECC		27.56-
210PhosphorylationYLSPSFDSVLPRYLF
EECCCHHHHHHHHHH		24.44-
215PhosphorylationFDSVLPRYLFLQNLP
HHHHHHHHHHHCCCC		10.40-
222UbiquitinationYLFLQNLPSALVSHV
HHHHCCCCHHHHHHH		25.7130230243
248UbiquitinationLCAAPGGKTTHIAAL
HHCCCCCCCCEEEEE		57.0529967540
262UbiquitinationLMHDQGEVIALDKIF
ECCCCCCEEEHHHHH		3.8730230243
271UbiquitinationALDKIFNKVEKIKQN
EHHHHHHHHHHHHHH		40.81-
271AcetylationALDKIFNKVEKIKQN
EHHHHHHHHHHHHHH		40.81164229
273UbiquitinationDKIFNKVEKIKQNAL
HHHHHHHHHHHHHHH		51.1530230243
274UbiquitinationKIFNKVEKIKQNALL
HHHHHHHHHHHHHHH		59.1830230243
274AcetylationKIFNKVEKIKQNALL
HHHHHHHHHHHHHHH		59.18164233
276AcetylationFNKVEKIKQNALLLG
HHHHHHHHHHHHHHC		48.87164237
286PhosphorylationALLLGLNSIRAFCFD
HHHHCCCCHHHHCCC		20.6324719451
296UbiquitinationAFCFDGTKAVKLDMV
HHCCCCCCEEEEEEE		57.63-
299UbiquitinationFDGTKAVKLDMVEDT
CCCCCEEEEEEEECC		43.56-
342UbiquitinationMACTWSVKEVASYQP
CCEEEEHHHHHHCCH		40.74-
415S-palmitoylationMRGAGLSCEQLKQLQ
CCCCCCCHHHHHHHH		4.6729575903
419UbiquitinationGLSCEQLKQLQRFDP
CCCHHHHHHHHCCCC		48.9719608861
419AcetylationGLSCEQLKQLQRFDP
CCCHHHHHHHHCCCC		48.9719608861
453UbiquitinationDMLRLANKDSIGFFI
HHHHHCCCCCHHHHE		47.4429967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NSUN6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NSUN6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NSUN6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPE_HUMANRPEphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NSUN6_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-419, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-151, AND MASSSPECTROMETRY.

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