NRX2A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRX2A_RAT
• UniProt AC: Q63374
• Protein Name: Neurexin-2
• Gene Name: Nrxn2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1715
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling..
• Protein Sequence: MALGSRWRPPPQLPPLLLLLALVAGVRGLEFGGGPGQWARYARWAGAASTGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEGEHPMEGPAHLTLNSPVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGAGVGSHSSSQRADYFAMELLDGYLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGESEVLDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSAAGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHTRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLLAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSVPGFPRLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	LSFSLRTNATRALLL CEEEECCCCCEEEEE	32.64	-
338	N-linked_Glycosylation	GKSADYVNLSLKSGA CCCCCEEEEEECCCC	20.06	-
844	N-linked_Glycosylation	SLQLSVDNVTVEGQM CEEEEEEEEEEEEEE	29.24	-
1239	N-linked_Glycosylation	RFTRSGGNATLQVDS EEEECCCCEEEEEEC	33.02	-
1475	Phosphorylation	PPAARRPSSGGPCQA CCCCCCCCCCCCCCC	39.54	27097102
1476	Phosphorylation	PAARRPSSGGPCQAE CCCCCCCCCCCCCCC	50.91	27097102
1670	Phosphorylation	YRNRDEGSYQVDQSR HCCCCCCCCEECCCC	15.45	25403869
1679	Phosphorylation	QVDQSRNYISNSAQS EECCCCCCCCCCHHH	12.48	22276854
1683	Phosphorylation	SRNYISNSAQSNGAV CCCCCCCCHHHCCCE	22.39	30240740
1692	Ubiquitination	QSNGAVVKEKAPAAP HHCCCEECCCCCCCC	47.07	-
1694	Ubiquitination	NGAVVKEKAPAAPKT CCCEECCCCCCCCCC	54.69	-
1700	Ubiquitination	EKAPAAPKTPSKAKK CCCCCCCCCCCHHCC	69.23	-
1701	Phosphorylation	KAPAAPKTPSKAKKN CCCCCCCCCCHHCCC	31.56	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRX2A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRX2A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRX2A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSKP_RAT	Cask	physical	8786425

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.