NRIF1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRIF1_RAT
• UniProt AC: Q4V8E9
• Protein Name: Neurotrophin receptor-interacting factor 1
• Gene Name: Nrif1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 822
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus.
• Protein Description: Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity)..
• Protein Sequence: MASTLPTTWPHESVKFEDVSLTFTKEEWAQLDLQQKCLYREIMMENYNNMISVEHHFSKPNVISQLEEAEDCWPMEREIRQDILPECSGPSLDPGMNSFPAESPLMKIKVVEVLTLNKDVAGPRNALIQSLYPESRENLNPGNLKPAKPSKRLTDTEALRQKFRHFQYEESAGPQKAVSRLRKLCHQWLQPNIRSKKQIIELLVFEQFLSALPEKFRVWLESQHPEDCRAAVALLENMTSVTKDDAQLVCSSEATDQLKEKRKDVATLPVTVPPEEPVTFQDVAVGFSQEEWRLLGPVQRTEYHDVMLETLGNLVSVGWEPTLENRAISPDSPIPVVKPIHDPNPKDLSRNGIQSTVFEIISQDRVQEIHTIESNQAGLLQEKSHPQKKLSESSKSQEGTNLHKSQGSLDEVPPRKHVKVKQKGTRKGKDRKNTISMTRGLRIRNQQKDSVEWQGRGDSNPMTHGYSIKNQRGSEQGTAGARRDPITLTVSAQFYQKATGSEEGRFRDNSNAIVPDTPTKIHQKSPEWHKVGRSNNSMSSVQNDQMGSGAGRGRDNTILTHALPVKIHQKGYEEGKVQGNRNSLRHVKAHQKGSKGERVRELSTSEKHVPYIKNHLKTSEREKGRENNDSIKYGPYIKTCYRGSEVRKLRRANNCTKAISRHAQQIFFIKIHKGSQVCRCSECGKMFRNSRYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCQHCGKAFRQSSHLTRHERTHTGERPYVCSNCGKAFTQSSHLIGHQKTHRIKFKKQPKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
329	Phosphorylation	TLENRAISPDSPIPV CCCCCCCCCCCCCCC	22.97	27097102
332	Phosphorylation	NRAISPDSPIPVVKP CCCCCCCCCCCCCCC	28.28	27097102
642	Methylation	PYIKTCYRGSEVRKL CCCCCCCCCHHHHHH	44.29	26494419
651	Methylation	SEVRKLRRANNCTKA HHHHHHHHHCCHHHH	52.70	26494423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRIF1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRIF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRIF1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_RAT	Traf6	physical	16252010
SQSTM_RAT	Sqstm1	physical	16252010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.