NR4A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR4A1_MOUSE
• UniProt AC: P12813
• Protein Name: Nuclear receptor subfamily 4 group A member 1
• Gene Name: Nr4a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 601
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity)..
• Protein Sequence: MPCIQAQYGTPATSPGPRDHLTGDPLALEFGKPTMDLASPETAPAAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSSACSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSEYYGSPCSAPSPSTPNFQPSQLSPWDGSFGHFSPSQTYEGLWAWTEQLPKASSGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPPPATHQLGEGESYSMPAAFPGLAPTSPNRDTSGILDAPVTSTKSRSGASGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQELVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHQLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMATVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	AQYGTPATSPGPRDH CCCCCCCCCCCCCHH	36.34	26824392
14	Phosphorylation	QYGTPATSPGPRDHL CCCCCCCCCCCCHHC	29.93	26824392
142	Phosphorylation	GSPCSAPSPSTPNFQ CCCCCCCCCCCCCCC	31.06	10878809
183	Phosphorylation	TEQLPKASSGPPPPP HHHCCCHHCCCCCCC	41.79	25777480
184	Phosphorylation	EQLPKASSGPPPPPT HHCCCHHCCCCCCCC	61.24	25777480
191	Phosphorylation	SGPPPPPTFFSFSPP CCCCCCCCEECCCCC	42.98	25777480
194	Phosphorylation	PPPPTFFSFSPPTGP CCCCCEECCCCCCCC	22.18	25777480
196	Phosphorylation	PPTFFSFSPPTGPSP CCCEECCCCCCCCCH	28.86	26824392
199	Phosphorylation	FFSFSPPTGPSPSLA EECCCCCCCCCHHHH	66.17	25777480
202	Phosphorylation	FSPPTGPSPSLAQSS CCCCCCCCHHHHHHH	28.59	25777480
204	Phosphorylation	PPTGPSPSLAQSSLK CCCCCCHHHHHHHHH	40.45	25777480
208	Phosphorylation	PSPSLAQSSLKLFPP CCHHHHHHHHHCCCC	31.84	25777480
209	Phosphorylation	SPSLAQSSLKLFPPP CHHHHHHHHHCCCCC	19.90	25777480
218	Phosphorylation	KLFPPPATHQLGEGE HCCCCCCCCCCCCCC	18.87	25777480
226	Phosphorylation	HQLGEGESYSMPAAF CCCCCCCCCCCCCCC	33.11	25777480
227	Phosphorylation	QLGEGESYSMPAAFP CCCCCCCCCCCCCCC	12.51	25777480
228	Phosphorylation	LGEGESYSMPAAFPG CCCCCCCCCCCCCCC	27.80	25777480
239	Phosphorylation	AFPGLAPTSPNRDTS CCCCCCCCCCCCCCC	51.73	25777480
240	Phosphorylation	FPGLAPTSPNRDTSG CCCCCCCCCCCCCCC	21.08	25777480
245	Phosphorylation	PTSPNRDTSGILDAP CCCCCCCCCCCCCCC	26.14	25777480
246	Phosphorylation	TSPNRDTSGILDAPV CCCCCCCCCCCCCCE	28.29	25777480
254	Phosphorylation	GILDAPVTSTKSRSG CCCCCCEEECCCCCC	29.62	25777480
255	Phosphorylation	ILDAPVTSTKSRSGA CCCCCEEECCCCCCC	33.79	25777480
256	Phosphorylation	LDAPVTSTKSRSGAS CCCCEEECCCCCCCC	24.55	25777480
344	Phosphorylation	KEVVRTDSLKGRRGR EEEEECCCCCCCCCC	31.22	26824392
354	Phosphorylation	GRRGRLPSKPKQPPD CCCCCCCCCCCCCCC	67.21	16223362
363	Phosphorylation	PKQPPDASPTNLLTS CCCCCCCCHHHHHHH	39.37	27600695
389	Acetylation	TAKLDYSKFQELVLP CCCCCHHHHHHHHCH	44.85	7623847

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
151	S	Phosphorylation	Kinase	CK2A1	Q60737	PSP
344	S	Phosphorylation	Kinase	PKA	-	Uniprot
354	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
354	S	Phosphorylation	Kinase	RPS6KA1	P18653	Uniprot
354	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
354	S	Phosphorylation	Kinase	RPS6KA3	P18654	Uniprot
354	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
354	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
354	S	Phosphorylation	Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR4A1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR0B1_MOUSE	Nr0b1	physical	15155786

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.