NMNA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMNA2_HUMAN
• UniProt AC: Q9BZQ4
• Protein Name: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 {ECO:0000305}
• Gene Name: NMNAT2 {ECO:0000312|HGNC:HGNC:16789}
• Organism: Homo sapiens (Human).
• Sequence Length: 307
• Subcellular Localization: Golgi apparatus membrane ; Lipid-anchor . Cytoplasmic vesicle membrane ; Lipid-anchor . Cytoplasm . Cell projection, axon . Delivered to axons with Golgi-derived cytoplasmic vesicles.
• Protein Description: Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. [PubMed: 16118205]
• Protein Sequence: MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQLYINASG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MTETTKTHVILLAC -CCCCCCCEEEEEEC	21.20	-
21	Phosphorylation	CGSFNPITKGHIQMF CCCCCCCCHHHHHHH	32.03	-
55	Phosphorylation	VSPVHDSYGKQGLVS ECCCCCCCCCCCCCC	34.11	22817900
62	Phosphorylation	YGKQGLVSSRHRLIM CCCCCCCCHHHEEEE	27.05	24719451
63	Phosphorylation	GKQGLVSSRHRLIMC CCCCCCCHHHEEEEE	25.32	26434776
150	Ubiquitination	VATKPTAAKILGKVG CCCCCCHHHHHHHHH	11.25	33845483
155	Ubiquitination	TAAKILGKVGESLSR CHHHHHHHHHHHHHH	43.55	33845483
164	S-palmitoylation	GESLSRICCVRPPVE HHHHHHEECCCCCCC	1.38	20943658
165	S-palmitoylation	ESLSRICCVRPPVER HHHHHEECCCCCCCE	2.43	20943658
237	Phosphorylation	VPRDAADTDRIMNHS EECCHHCCHHHHCHH	23.58	25367220
245	Phosphorylation	DRIMNHSSILRKYKN HHHHCHHHHHHHHCC	20.35	24719451
250	Phosphorylation	HSSILRKYKNNIMVV HHHHHHHHCCCEEEE	16.71	-
266	Phosphorylation	DDINHPMSVVSSTKS CCCCCCHHHCCCCCC	24.66	27134283
267	Ubiquitination	DINHPMSVVSSTKSR CCCCCHHHCCCCCCE	3.83	29967540
271	Phosphorylation	PMSVVSSTKSRLALQ CHHHCCCCCCEEEHH	26.07	27134283
272	Ubiquitination	MSVVSSTKSRLALQH HHHCCCCCCEEEHHC	35.21	29967540
273	Phosphorylation	SVVSSTKSRLALQHG HHCCCCCCEEEHHCC	32.39	27134283
287	Phosphorylation	GDGHVVDYLSQPVID CCCCHHHCCCHHHHH	9.17	25884760
295	Phosphorylation	LSQPVIDYILKSQLY CCHHHHHHHHHHCCE	9.31	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMNA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMNA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMNA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.