NMDE4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMDE4_RAT
• UniProt AC: Q62645
• Protein Name: Glutamate receptor ionotropic, NMDA 2D
• Gene Name: Grin2d
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1323
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). [PubMed: 7512349]
• Protein Sequence: MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAVGGGTGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRTQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAAIADGFHRYYGPIEPQGLGLGEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPTEPPAGAFPGFPSPPAPPAAAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAAPPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDFPPPAPTSRSLEDLSSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	N-linked_Glycosylation	RPVALVLNGSDPRSL CCEEEEECCCCHHHH	40.21	-
349	N-linked_Glycosylation	GHDCRTQNRTHRGES CCCCCCCCCCCCCCC	50.64	-
363	N-linked_Glycosylation	SLHRYFMNITWDNRD CHHHHEEECEECCCC	20.74	-
381	N-linked_Glycosylation	NEDGFLVNPSLVVIS CCCCCCCCCEEEEEE	23.69	-
464	N-linked_Glycosylation	VPCRSQLNRTHSPPP CCCHHHCCCCCCCCC	38.89	-
566	N-linked_Glycosylation	SVMVARSNGTVSPSA EEEEEECCCCCCHHH	44.60	-
712	N-linked_Glycosylation	LKFGTVPNGSTEKNI CCCCCCCCCCCCCCH	53.35	-
961	Phosphorylation	IADGFHRYYGPIEPQ ECCCCHHHCCCCCCC	12.28	-
962	Phosphorylation	ADGFHRYYGPIEPQG CCCCHHHCCCCCCCC	19.18	-
988	Phosphorylation	GAAGRPLSPPTTQPP CCCCCCCCCCCCCCC	31.36	30240740
1049	Phosphorylation	RLAFEDESPPAPSRW EEECCCCCCCCCCCC	48.80	28551015
1303	Methylation	TASHRRHRGGDLGTR CCCCCCCCCCCCCCC	49.32	-
1313	Phosphorylation	DLGTRRGSAHFSSLE CCCCCCCCCCHHHCC	19.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMDE4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMDE4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMDE4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_RAT	Nedd4	physical	23639431
IL16_MOUSE	Il16	physical	10479680

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.