NKG2D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKG2D_HUMAN
• UniProt AC: P26718
• Protein Name: NKG2-D type II integral membrane protein
• Gene Name: KLRK1
• Organism: Homo sapiens (Human).
• Sequence Length: 216
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein . Colocalized with HCST on the cell surface.
• Protein Description: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4..
• Protein Sequence: MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVAIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GWIRGRRSRHSWEMS CCCCCCCCCCCEEHH	32.74	29978859
12	Phosphorylation	RGRRSRHSWEMSEFH CCCCCCCCEEHHHHH	24.50	29978859
16	Phosphorylation	SRHSWEMSEFHNYNL CCCCEEHHHHHCCCC	26.12	29978859
21	Phosphorylation	EMSEFHNYNLDLKKS EHHHHHCCCCCCCCC	14.45	29978859
121	Phosphorylation	FDESKNWYESQASCM ECCCCCHHHHHHHHH	18.33	28985074
123	Phosphorylation	ESKNWYESQASCMSQ CCCCHHHHHHHHHHC	18.49	28985074
131	N-linked_Glycosylation	QASCMSQNASLLKVY HHHHHHCCHHHEEEE	24.96	UniProtKB CARBOHYD
133	Phosphorylation	SCMSQNASLLKVYSK HHHHCCHHHEEEECH	41.61	24719451
163	N-linked_Glycosylation	GLVHIPTNGSWQWED EEEEECCCCCEECCC	36.83	UniProtKB CARBOHYD
202	N-linked_Glycosylation	SFKGYIENCSTPNTY HHCHHHHCCCCCCEE	18.58	UniProtKB CARBOHYD
205	Phosphorylation	GYIENCSTPNTYICM HHHHCCCCCCEEEEE	23.82	-
209	Phosphorylation	NCSTPNTYICMQRTV CCCCCCEEEEEEECC	9.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKG2D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKG2D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKG2D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAE1L_HUMAN	RAE1	physical	11520456

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.