NKAIN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKAIN_DROME
• UniProt AC: A6MHQ4
• Protein Name: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
• Gene Name: NKAIN
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 658
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Induces a small but significant sodium conductance when expressed in Xenopus oocytes..
• Protein Sequence: MGSCSCTRRHFLLSICFLQVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFYLNVGQLNRDSDLLNLGTGSVSWFEANGYGCKPTYNMAADDTFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILGAILISCIFLDEDDRFDFMNGDAKSPQHTVVHPMYVSYTSIPTTSASATMQSNKHLQLQHQQPQQNSLKLYHHQQQQQPKLHHFNKNYQLSGSNNNTLNNNLHQRAPALLPPNTTNNRSASFQTQSHPSNNHVTQRTGGEGSNCSSLRRHRQHHSKALVSPSPMSPQTTPSLSYASLQNSSPYLAGNSLSNSNYSIFQSPDSLQGSSHFARIHHKPKPPKSDYPVSGEFNPGGNISSPVRPLDRLSRSLEDDEDNFSLQKFAPGEHGVTYVPFQSPTPNSLFLGENNNSQPHLVFHTNSRSSPNNNAYPYDQSGLPSSLRMGSNSNARRPTHIPLPTVPMHNCQEVENDEDADGESEQDHDQMLTPPPPPLVRPHIHQRLGQAPYLDLSPEVAERYAIPSKLGPSLPIQVPLPVPHGSPMVRRSNRRPRPSNPVNFCDQIRATPPGYVVRAQSDDRLMEQVEADAAPHVNRRSGRGGSGQKTRPRSFCNSIVGVQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
229	Phosphorylation	HQQPQQNSLKLYHHQ CCCCCHHHHHHHHHH	23.65	19429919
233	Phosphorylation	QQNSLKLYHHQQQQQ CHHHHHHHHHHHHHC	8.82	19429919
250	Phosphorylation	LHHFNKNYQLSGSNN CCCCCCCCCCCCCCC	16.67	18281928
257	N-linked_Glycosylation	YQLSGSNNNTLNNNL CCCCCCCCCCCCCCH	44.56	-
275	N-linked_Glycosylation	APALLPPNTTNNRSA CCCCCCCCCCCCCCC	58.56	-
279	N-linked_Glycosylation	LPPNTTNNRSASFQT CCCCCCCCCCCCCCC	36.87	-
291	Phosphorylation	FQTQSHPSNNHVTQR CCCCCCCCCCCCCCC	44.85	18327897
305	N-linked_Glycosylation	RTGGEGSNCSSLRRH CCCCCCCCHHHHHHH	40.31	-
307	Phosphorylation	GGEGSNCSSLRRHRQ CCCCCCHHHHHHHHH	36.34	27626673
308	Phosphorylation	GEGSNCSSLRRHRQH CCCCCHHHHHHHHHH	28.26	25749252
355	N-linked_Glycosylation	GNSLSNSNYSIFQSP CCCCCCCCCCCCCCC	38.53	-
396	N-linked_Glycosylation	GEFNPGGNISSPVRP CCCCCCCCCCCCCCC	36.56	-
398	Phosphorylation	FNPGGNISSPVRPLD CCCCCCCCCCCCCHH	32.37	18327897
399	Phosphorylation	NPGGNISSPVRPLDR CCCCCCCCCCCCHHH	24.50	12537569
417	N-linked_Glycosylation	SLEDDEDNFSLQKFA CCCCCCCCCCCCCCC	26.76	-
419	Phosphorylation	EDDEDNFSLQKFAPG CCCCCCCCCCCCCCC	35.82	25749252
449	N-linked_Glycosylation	SLFLGENNNSQPHLV CEEECCCCCCCCEEE	45.27	-
472	Phosphorylation	PNNNAYPYDQSGLPS CCCCCCCCCCCCCCC	17.59	18281928
580	Phosphorylation	PLPVPHGSPMVRRSN CCCCCCCCCCCCCCC	13.54	23607784
615	Phosphorylation	GYVVRAQSDDRLMEQ CEEEEECCCCHHHHH	40.26	22668510
648	Phosphorylation	GQKTRPRSFCNSIVG CCCCCCCCHHHHHCC	36.51	29892262
652	Phosphorylation	RPRSFCNSIVGVQG- CCCCHHHHHCCCCC-	21.60	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKAIN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKAIN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKAIN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPB2_DROME	nrv2	physical	17606467

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291; SER-308; SER-398AND SER-399, AND MASS SPECTROMETRY.
PubMed: 18327897