NICA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NICA_RAT
• UniProt AC: Q8CGU6
• Protein Name: Nicastrin
• Gene Name: Ncstn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 708
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
• Protein Description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels..
• Protein Sequence: MATARGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEDDLKWVLTDGPNPPYMVLLEGKLFTRDIMEKLKGETSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYDDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSGGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLELWMHTDPMSQKNESVKNQVEDLLVTLEQSGADTPQVVLSRLVQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPESQSPEEDLNFVTDTAKALADVATVLARALYKLAGGTNFNNSIQADPQTVTRLLYGFLVRANNSWFQSILRHDLRSYLDDGPLQHYIAVSSPTNTTYVVQYALANLTGKVTNLTQEQCQDPSKVPNESKDLYEYSWVQGPWNSNKTERLPRCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSILVFSLIVTYCINAKADVLFVAPREPGAVSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	N-linked_Glycosylation	RKIYIPLNKTAPCVR EEEEEECCCCCHHHH	33.99	-
54	N-linked_Glycosylation	APCVRLLNATHQIGC CHHHHHHCCCCCCCC	47.59	-
128	N-linked_Glycosylation	AVTLAKPNSTSSFSP EEEECCCCCCCCCCC	58.16	-
186	N-linked_Glycosylation	IFLLEDENETKVIKQ EEEECCCCCHHHHHH	74.65	-
203	N-linked_Glycosylation	QDHNLGQNGSAPSFP HHCCCCCCCCCCCHH	44.59	-
263	N-linked_Glycosylation	WSMLKPINTSGGLEP HHHCEECCCCCCCCC	36.40	-
386	N-linked_Glycosylation	TDPMSQKNESVKNQV CCCCCCCCHHHHHHH	38.86	-
434	N-linked_Glycosylation	QRFLRARNISGVVLA HHHHHHCCCCCEEEE	31.62	24090084
463	N-linked_Glycosylation	YDTAENINVTYPESQ HHHHHHEECCCCCCC	31.49	-
507	N-linked_Glycosylation	LAGGTNFNNSIQADP HHCCCCCCCCCCCCH	43.33	-
529	N-linked_Glycosylation	YGFLVRANNSWFQSI HHHHHHCCCHHHHHH	32.29	-
561	N-linked_Glycosylation	IAVSSPTNTTYVVQY EEEECCCCHHHHHHH	33.53	-
572	N-linked_Glycosylation	VVQYALANLTGKVTN HHHHHHHHCCCCEEE	38.70	-
579	N-linked_Glycosylation	NLTGKVTNLTQEQCQ HCCCCEEECCHHHHC	44.04	-
593	N-linked_Glycosylation	QDPSKVPNESKDLYE CCCCCCCCCCCCCCC	69.98	-
611	N-linked_Glycosylation	VQGPWNSNKTERLPR CCCCCCCCHHHCHHH	52.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NICA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NICA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NICA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERLN2_RAT	Erlin2	physical	22771797

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.