ERLN2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERLN2_RAT
• UniProt AC: B5DEH2
• Protein Name: Erlin-2 {ECO:0000250|UniProtKB:Q8BFZ9}
• Gene Name: Erlin2 {ECO:0000312|EMBL:AAI68668.1, ECO:0000312|RGD:1309010}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 339
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
• Protein Description: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity)..
• Protein Sequence: MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	N-linked_Glycosylation	AVYDIVKNYTADYDK HHHHHHHHCCCCHHH	28.61	-
263	Phosphorylation	AKADAECYTALKIAE HHCCHHHHHHHHHHH	6.12	-
267	Acetylation	AECYTALKIAEANKL HHHHHHHHHHHHHCC	37.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERLN2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERLN2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERLN2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSN1_RAT	Psen1	physical	22771797
NICA_RAT	Ncstn	physical	22771797

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.