NHX7_ARATH - dbPTM
NHX7_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NHX7_ARATH
UniProt AC Q9LKW9
Protein Name Sodium/hydrogen exchanger 7
Gene Name NHX7
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 1146
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Acts in electroneutral exchange of protons for cations such as Na(+) or Li(+) across plasma membrane. Involved in Na(+) and K(+) homeostasis. Required for cytoplasmic Na(+) and Li(+) detoxification by secreting them from the cytoplasm to the extracellular space. Regulates Na(+) content of the xylem sap..
Protein Sequence MTTVIDATMAYRFLEEATDSSSSSSSSKLESSPVDAVLFVGMSLVLGIASRHLLRGTRVPYTVALLVIGIALGSLEYGAKHNLGKIGHGIRIWNEIDPELLLAVFLPALLFESSFSMEVHQIKRCLGQMVLLAVPGVLISTACLGSLVKVTFPYEWDWKTSLLLGGLLSATDPVAVVALLKELGASKKLSTIIEGESLMNDGTAIVVFQLFLKMAMGQNSDWSSIIKFLLKVALGAVGIGLAFGIASVIWLKFIFNDTVIEITLTIAVSYFAYYTAQEWAGASGVLTVMTLGMFYAAFARTAFKGDSQKSLHHFWEMVAYIANTLIFILSGVVIAEGILDSDKIAYQGNSWRFLFLLYVYIQLSRVVVVGVLYPLLCRFGYGLDWKESIILVWSGLRGAVALALSLSVKQSSGNSHISKETGTLFLFFTGGIVFLTLIVNGSTTQFVLRLLRMDILPAPKKRILEYTKYEMLNKALRAFQDLGDDEELGPADWPTVESYISSLKGSEGELVHHPHNGSKIGSLDPKSLKDIRMRFLNGVQATYWEMLDEGRISEVTANILMQSVDEALDQVSTTLCDWRGLKPHVNFPNYYNFLHSKVVPRKLVTYFAVERLESACYISAAFLRAHTIARQQLYDFLGESNIGSIVINESEKEGEEAKKFLEKVRSSFPQVLRVVKTKQVTYSVLNHLLGYIENLEKVGLLEEKEIAHLHDAVQTGLKKLLRNPPIVKLPKLSDMITSHPLSVALPPAFCEPLKHSKKEPMKLRGVTLYKEGSKPTGVWLIFDGIVKWKSKILSNNHSLHPTFSHGSTLGLYEVLTGKPYLCDLITDSMVLCFFIDSEKILSLQSDSTIDDFLWQESALVLLKLLRPQIFESVAMQELRALVSTESSKLTTYVTGESIEIDCNSIGLLLEGFVKPVGIKEELISSPAALSPSNGNQSFHNSSEASGIMRVSFSQQATQYIVETRARAIIFNIGAFGADRTLHRRPSSLTPPRSSSSDQLQRSFRKEHRGLMSWPENIYAKQQQEINKTTLSLSERAMQLSIFGSMVNVYRRSVSFGGIYNNKLQDNLLYKKLPLNPAQGLVSAKSESSIVTKKQLETRKHACQLPLKGESSTRQNTMVESSDEEDEDEGIVVRIDSPSKIVFRNDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
951PhosphorylationASGIMRVSFSQQATQ
CCCEEEEEECHHCHH		14.6030407730
953PhosphorylationGIMRVSFSQQATQYI
CEEEEEECHHCHHHH		17.5530407730
986PhosphorylationRTLHRRPSSLTPPRS
CCCCCCCCCCCCCCC		35.8525561503
995PhosphorylationLTPPRSSSSDQLQRS
CCCCCCCCHHHHHHH		38.9025561503
1012PhosphorylationKEHRGLMSWPENIYA
HHHHHHCCCCCHHHH		44.5130407730
1018PhosphorylationMSWPENIYAKQQQEI
CCCCCHHHHHHHHHH		21.2330407730
1029PhosphorylationQQEINKTTLSLSERA
HHHHHHHHCCHHHHH		18.8925561503
1031PhosphorylationEINKTTLSLSERAMQ
HHHHHHCCHHHHHHH		27.9729654922
1033PhosphorylationNKTTLSLSERAMQLS
HHHHCCHHHHHHHHH		22.9730407730
1040PhosphorylationSERAMQLSIFGSMVN
HHHHHHHHHHHHHHH		10.0528295753
1044PhosphorylationMQLSIFGSMVNVYRR
HHHHHHHHHHHHHHC		14.6028295753
1049PhosphorylationFGSMVNVYRRSVSFG
HHHHHHHHHCCCCCC		8.6328295753
1052PhosphorylationMVNVYRRSVSFGGIY
HHHHHHCCCCCCCCC		17.0815308754
1054PhosphorylationNVYRRSVSFGGIYNN
HHHHCCCCCCCCCCC		21.3019880383
1059PhosphorylationSVSFGGIYNNKLQDN
CCCCCCCCCCCCCCC		18.8925561503
1085PhosphorylationQGLVSAKSESSIVTK
CCCCCCCCCCCCCCH		42.2930291188
1087PhosphorylationLVSAKSESSIVTKKQ
CCCCCCCCCCCCHHH		32.2425561503
1088PhosphorylationVSAKSESSIVTKKQL
CCCCCCCCCCCHHHH		19.6125561503
1116PhosphorylationESSTRQNTMVESSDE
CCCCCCCCEEECCCC		17.7923776212
1120PhosphorylationRQNTMVESSDEEDED
CCCCEEECCCCCCCC		31.5123776212
1121PhosphorylationQNTMVESSDEEDEDE
CCCEEECCCCCCCCC		35.2223776212
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NHX7_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NHX7_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NHX7_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RCD1_ARATHRCD1physical
17023541
NHX7_ARATHSOS1physical
23022605
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NHX7_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Novel subsets of the Arabidopsis plasmalemma phosphoproteome identifyphosphorylation sites in secondary active transporters.";
Hem S., Rofidal V., Sommerer N., Rossignol M.;
Biochem. Biophys. Res. Commun. 363:375-380(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1120 AND SER-1121, ANDMASS SPECTROMETRY.
"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Plant Cell 16:2394-2405(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1052, AND MASSSPECTROMETRY.
"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054, AND MASSSPECTROMETRY.

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