NHR49_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NHR49_CAEEL
• UniProt AC: O45666
• Protein Name: Nuclear hormone receptor family member nhr-49
• Gene Name: nhr-49
• Organism: Caenorhabditis elegans.
• Sequence Length: 501
• Subcellular Localization: Nucleus .
• Protein Description: Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7. [PubMed: 25981666]
• Protein Sequence: MDYFLDASKHIQLNQIDEESSDDFMDLVDPLAEPCAVCGDKSTGTHYGVISCNGCKGFFRRTVLRDQKFTCRFNKRCVIDKNFRCACRYCRFQKCVQVGMKREAIQFERDPVGSPTSGASLNGTPFKKDRSPGYENGNSNGVGSNGMGQENMRTVPQSSSVIDALMEMEARVNQEMCNRYRRSQIFANGSGGSNGNDTDIQQGSDSGASAFAPPNRPCTTEVDLNEISRTTLLLMVEWAKTINPFMDLSMEDKIILLKNYAPQHLILMPAFRSPDTTRVCLFNNTYMTRDNNTDLNGFAAFKTSNITPRVLDEIVWPMRQLQMREQEFVCLKALAFLHPEAKGLSNSSQIMIRDARNRVLKALYAFILDQMPDDAPTRYGNILLLAPALKALTQLLIENMTLTKFFGLAEVDSLLSEFILDDINDHSTAPVSLQQHLSSPTTLPTNGVSPLNPAGSVGSVSSVSGITPTGMLSATLAAPLAIHPLQSQDSILNSEQNNHML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Phosphorylation	FERDPVGSPTSGASL EECCCCCCCCCCCCC	25.82	28854356
116	Phosphorylation	RDPVGSPTSGASLNG CCCCCCCCCCCCCCC	41.30	19530675
117	Phosphorylation	DPVGSPTSGASLNGT CCCCCCCCCCCCCCC	35.43	19530675
120	Phosphorylation	GSPTSGASLNGTPFK CCCCCCCCCCCCCCC	26.37	19530675
124	Phosphorylation	SGASLNGTPFKKDRS CCCCCCCCCCCCCCC	25.20	19530675
131	Phosphorylation	TPFKKDRSPGYENGN CCCCCCCCCCCCCCC	32.58	28854356
134	Phosphorylation	KKDRSPGYENGNSNG CCCCCCCCCCCCCCC	15.03	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NHR49_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NHR49_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NHR49_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHR22_CAEEL	nhr-22	physical	14704431
NHR49_CAEEL	nhr-49	physical	14704431
NHR71_CAEEL	nhr-71	physical	14704431
NHR79_CAEEL	nhr-79	physical	14704431
NHR13_CAEEL	nhr-13	physical	14704431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.