NEU1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEU1_HUMAN
• UniProt AC: P01178
• Protein Name: Oxytocin-neurophysin 1
• Gene Name: OXT
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Secreted.
• Protein Description: Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR). [PubMed: 18174156]
• Protein Sequence: MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Glycine amide	YIQNCPLGGKRAAPD HHHCCCCCCCCCCCC	25.39	-
28	Amidation	YIQNCPLGGKRAAPD HHHCCCCCCCCCCCC	25.39	13591312

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEU1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEU1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEU1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHC1_HUMAN	SHC1	physical	28514442
VHL_HUMAN	VHL	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
NIF3L_HUMAN	NIF3L1	physical	28514442
NFS1_HUMAN	NFS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.