dbPTM

NEK10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEK10_MOUSE
UniProt AC	Q3UGM2
Protein Name	Serine/threonine-protein kinase Nek10
Gene Name	Nek10 {ECO:0000312\|MGI:MGI:2685128}
Organism	Mus musculus (Mouse).
Sequence Length	1111
Subcellular Localization
Protein Description
Protein Sequence	MPDQDTKAKSTEKTADKQQGTTTRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNNMTKSEPTIRTGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQHQLFQEIFTALVRNRLICREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHKLGGIEDLAQYMEIVANEYLGYAEEQHCVDKLVNMTYIFQKLAAVKDQREWVTASGAHKTLVSLLGARDTTVLLGALLALASLAESSECREKISELNVVENLLMILHEYDLLSKRLTAELLRLLCAEPQIKEQVKLYEGIPILLSLLHSDHLKLLWSVIWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDRSSIGSLSSANAAGRIQQLHLSEDLSPGEIEENTVSLQAACCAALTELALNDTNAHQVVQENGVYTIAKLILPNKQSNAAQTNLLQCYAFRTLRFLFSMERNRPLFKRLFPTDLFETFIDIGHYVRDIGAYKDLVSQLNLLLEDELKQIAENIESINQKKAPLKYIGDYAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFNSLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQESSKLTSMVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDIVEVSSMISDVMMKYLDRLSTSQLALERKLERERRRTQRYFMEANRNAVTCHHELALLSQETFEKASLSSSSSGAASLKSELSESAELPGEGCHIPCGKEEDRVCEEVLSEDNFQLESVEKDLYSELDDELDVSDNCSSSSSSPLKESTFSILKRSFSASGRERHSQARDFIAGLGSRPRPGPQMSTFVVESASAGIAVSQRKVRQICDPIQQILIQLHKVIYITQLPPALHHDLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIELNFLTSDYHSLRHSRAANNWSPSDPTGSPSSFEVEEGVTYEQMQTVIEEVLEESGYYNFTTKR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
63	Phosphorylation	NMTKSEPTIRTGGHR CCCCCCCCEECCCCC	21.02	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NEK10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NEK10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEK10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RAF1_MOUSE	Raf1	physical	20956560
MP2K1_MOUSE	Map2k1	physical	20956560

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEK10_MOUSE

Related Literatures of Post-Translational Modification