NDKB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDKB_RAT
• UniProt AC: P19804
• Protein Name: Nucleoside diphosphate kinase B
• Gene Name: Nme2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 152
• Subcellular Localization: Cytoplasm . Nucleus . Cell projection, lamellipodium . Cell projection, ruffle . Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vi
• Protein Description: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Exhibits histidine protein kinase activity (By similarity)..
• Protein Sequence: MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFKPEELIDYKSCAHDWVYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	ERTFIAIKPDGVQRG EEEEEEECCCCHHHC	28.21	-
12	Acetylation	ERTFIAIKPDGVQRG EEEEEEECCCCHHHC	28.21	22902405
12	Succinylation	ERTFIAIKPDGVQRG EEEEEEECCCCHHHC	28.21	26843850
26	Acetylation	GLVGEIIKRFEQKGF CHHHHHHHHHHHCCH	57.61	13581495
31	Acetylation	IIKRFEQKGFRLVAM HHHHHHHCCHHHHHH	53.47	22902405
39	Acetylation	GFRLVAMKFLRASEE CHHHHHHHHHHHCHH	31.35	22902405
44	Phosphorylation	AMKFLRASEEHLKQH HHHHHHHCHHHHHHH	36.76	23991683
49	Acetylation	RASEEHLKQHYIDLK HHCHHHHHHHCCCCC	36.62	22902405
49	Ubiquitination	RASEEHLKQHYIDLK HHCHHHHHHHCCCCC	36.62	-
56	Acetylation	KQHYIDLKDRPFFPG HHHCCCCCCCCCCCC	48.20	22902405
56	Ubiquitination	KQHYIDLKDRPFFPG HHHCCCCCCCCCCCC	48.20	-
94	Phosphorylation	GRVMLGETNPADSKP CCEEECCCCCCCCCC	44.71	23991683
99	Phosphorylation	GETNPADSKPGTIRG CCCCCCCCCCCCCCC	42.74	27097102
100	Acetylation	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	22902405
100	Ubiquitination	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	-
103	Phosphorylation	PADSKPGTIRGDFCI CCCCCCCCCCCCEEE	18.94	23991683
120	Phosphorylation	GRNIIHGSDSVESAE CCCEECCCCCHHHHH	16.73	23991683
122	Phosphorylation	NIIHGSDSVESAEKE CEECCCCCHHHHHHH	29.49	23991683
125	Phosphorylation	HGSDSVESAEKEIGL CCCCCHHHHHHHHCC	39.30	25532521
128	Acetylation	DSVESAEKEIGLWFK CCHHHHHHHHCCCCC	55.11	22902405
135	Acetylation	KEIGLWFKPEELIDY HHHCCCCCHHHHCCC	39.68	22902405
135	Succinylation	KEIGLWFKPEELIDY HHHCCCCCHHHHCCC	39.68	26843850

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
94	T	Phosphorylation	Kinase	CDK1	P06493	PSP
120	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDKB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDKB_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHOCN_RAT	Mob4	physical	11872741
DYN1_RAT	Dnm1	physical	11872741

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.