NBR1_RAT - dbPTM
NBR1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NBR1_RAT
UniProt AC Q501R9
Protein Name Next to BRCA1 gene 1 protein
Gene Name Nbr1
Organism Rattus norvegicus (Rat).
Sequence Length 983
Subcellular Localization Cytoplasm . Cytoplasmic vesicle, autophagosome . Lysosome . Cytoplasm, myofibril, sarcomere, M line . In cardiac muscles localizes to the sarcomeric M line (PubMed:15802564). Is targeted to lysosomes for degradation (By similarity).
Protein Description Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets..
Protein Sequence MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGCHVVDEVLPQTVVEKQATARTGKKPLAHYSSLVRVLGSDMKTTEEPTAEARSPVPCDTDKPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPPFSSSPSEVSMPISEEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYSHDTNHILLKFRRPVVISSEPFFYSKYPTPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHIGVVSVEFIAPTLEGTYTLHWRLSHKGQQFGPRVWCSIIVDPFPSSESPVNLERDGISSSKADDFTCEQEEAFLLAEEEIPLGEVTKQTEGTGSSAPQKTQHAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPRMSPLPHDSPLIEKPGLGRIQEESEGAGLKASPDSTVLTKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEEQQPLMLPGFCRKDSSLKFALPEEGPHGDEREEIVHIAEEEAIEEEDVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGQEPAEARERLPERESQPKEQSISDILTTSQHLDTVPLVPEVAGLPAALSRSAPCGQYEAPRVDSPVTIQEVLPVPDHVRGEPRGSTGLANSRQKSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPVISEDQTAALMAHLFEMGFCDRQLNLRLLRKHNHNILQVVTELLQVNNNDWYSHRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
115PhosphorylationGKKPLAHYSSLVRVL
CCCCCCCHHHHHHHH		8.3727097102
116PhosphorylationKKPLAHYSSLVRVLG
CCCCCCHHHHHHHHC		13.8228432305
117PhosphorylationKPLAHYSSLVRVLGS
CCCCCHHHHHHHHCC		24.5828432305
127UbiquitinationRVLGSDMKTTEEPTA
HHHCCCCCCCCCCCC		58.23-
138PhosphorylationEPTAEARSPVPCDTD
CCCCCCCCCCCCCCC		36.9827097102
144PhosphorylationRSPVPCDTDKPQDKP
CCCCCCCCCCCCCCC		53.2727097102
301AcetylationQVDKNFVKAEKQRLR
HHCHHHHHHHHHHHH		46.8422902405
342PhosphorylationNSIHGLQSPKSPLGR
HHHCCCCCCCCCCCC		39.0627097102
466UbiquitinationLHWRLSHKGQQFGPR
EEEEECCCCCCCCCE		55.85-
485PhosphorylationIIVDPFPSSESPVNL
EEECCCCCCCCCCCC		47.3027097102
486PhosphorylationIVDPFPSSESPVNLE
EECCCCCCCCCCCCC		42.1927097102
488PhosphorylationDPFPSSESPVNLERD
CCCCCCCCCCCCCCC		35.7827097102
529PhosphorylationLGEVTKQTEGTGSSA
CCCCCCCCCCCCCCC		37.6326022182
583PhosphorylationLERVPHNTPVDVTPR
HCCCCCCCCCCCCCC		22.9628432305
588PhosphorylationHNTPVDVTPRMSPLP
CCCCCCCCCCCCCCC		10.7427097102
592PhosphorylationVDVTPRMSPLPHDSP
CCCCCCCCCCCCCCC		25.2727097102
598PhosphorylationMSPLPHDSPLIEKPG
CCCCCCCCCCCCCCC		20.6927097102
621PhosphorylationEGAGLKASPDSTVLT
CCCCCCCCCCCCEEE		27.8727097102
634PhosphorylationLTKRKAETPASVEET
EECCCCCCCCCHHCC		29.0825575281
637PhosphorylationRKAETPASVEETEED
CCCCCCCCHHCCHHH		31.1225575281
641PhosphorylationTPASVEETEEDLSGT
CCCCHHCCHHHHCCC		31.0425575281
646PhosphorylationEETEEDLSGTQFVCE
HCCHHHHCCCHHHHH		52.7125575281
648PhosphorylationTEEDLSGTQFVCETV
CHHHHCCCHHHHHHH		18.5625575281
654PhosphorylationGTQFVCETVIRSLTL
CCHHHHHHHHHHCCC		18.9925575281
658PhosphorylationVCETVIRSLTLDAAP
HHHHHHHHCCCCCCC		18.0029779826
660PhosphorylationETVIRSLTLDAAPDH
HHHHHHCCCCCCCCC		24.6827097102
767PhosphorylationTSRPLGDSMYSSALS
CCCCCCHHHHHHHHC		20.1627097102
769PhosphorylationRPLGDSMYSSALSQP
CCCCHHHHHHHHCCC		11.9227097102
770PhosphorylationPLGDSMYSSALSQPG
CCCHHHHHHHHCCCC		10.6527097102
771PhosphorylationLGDSMYSSALSQPGL
CCHHHHHHHHCCCCC		18.7527097102
774PhosphorylationSMYSSALSQPGLERG
HHHHHHHCCCCCCCC		33.7627097102
812PhosphorylationESQPKEQSISDILTT
CCCCCCCCHHHHHHH		25.7527097102
814PhosphorylationQPKEQSISDILTTSQ
CCCCCCHHHHHHHHC		24.6827097102
818PhosphorylationQSISDILTTSQHLDT
CCHHHHHHHHCCCCC		25.4127097102
819PhosphorylationSISDILTTSQHLDTV
CHHHHHHHHCCCCCC		23.9727097102
820PhosphorylationISDILTTSQHLDTVP
HHHHHHHHCCCCCCC		15.4627097102
825PhosphorylationTTSQHLDTVPLVPEV
HHHCCCCCCCCCHHH		30.3127097102
842PhosphorylationLPAALSRSAPCGQYE
CCHHHCCCCCCCCCC		32.9428432305
855PhosphorylationYEAPRVDSPVTIQEV
CCCCCCCCCEEEEEE		20.5729779826
858PhosphorylationPRVDSPVTIQEVLPV
CCCCCCEEEEEEECC		21.9628432305
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NBR1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NBR1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NBR1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRI63_RATTrim63physical
15802564
TRI55_RATTrim55physical
15802564
SQSTM_RATSqstm1physical
15802564
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NBR1_RAT

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Related Literatures of Post-Translational Modification

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