NAR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAR4_HUMAN
• UniProt AC: Q93070
• Protein Name: Ecto-ADP-ribosyltransferase 4
• Gene Name: ART4
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Sequence: MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGNWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KKILLPTTVPPATMR CHHCCCCCCCHHHHH	29.13	22817900
21	Phosphorylation	PTTVPPATMRIWLLG CCCCCHHHHHHHHHH	16.86	22817900
114	N-linked_Glycosylation	QGKVLPQNMTTTHAV CCCCCCCCCCHHHHH	28.03	UniProtKB CARBOHYD
178	N-linked_Glycosylation	RKDSIMENGTLCYEV HHCCCCCCCEEEEEE	31.22	UniProtKB CARBOHYD
211	Phosphorylation	FGQFLSTSLLKEEAQ HHHHHCHHHHHHHHH	28.47	24719451
222	N-linked_Glycosylation	EEAQEFGNQTLFTIF HHHHHHCHHHHHHHH	36.66	UniProtKB CARBOHYD
257	N-linked_Glycosylation	YELFKVINMSYHPRG HHHHHHCCEEECCCC	19.14	UniProtKB CARBOHYD
274	N-linked_Glycosylation	LQLRSTGNLSTYNCQ EEEEECCCCCHHCCH	30.79	UniProtKB CARBOHYD
285	GPI-anchor	YNCQLLKASSKKCIP HCCHHHHHCCCCCCC	21.00	-
310	Phosphorylation	LTSVIIFSKSRV--- HHHHHHHCCCCC---	21.22	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CBLL1	Q75N03	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.