NANO3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NANO3_HUMAN
• UniProt AC: P60323
• Protein Name: Nanos homolog 3
• Gene Name: NANOS3
• Organism: Homo sapiens (Human).
• Sequence Length: 173
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, Stress granule . Cytoplasm, P-body . Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body.
• Protein Description: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis..
• Protein Sequence: MGTFDLWTDYLGLAHLVRALSGKEGPETRLSPQPEPEPMLEPDQKRSLESSPAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATRERAHTRRFCPLTGQGYTSVYSHTTRNSAGKKLVRPDKAKTQDTGHRRGGGGGAGFRGAGKSEPSPSCSPSMST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	LEPDQKRSLESSPAP CCHHHHHCCCCCCCH	43.45	-
146	Methylation	KTQDTGHRRGGGGGA CCCCCCCCCCCCCCC	40.04	24411165
147	Methylation	TQDTGHRRGGGGGAG CCCCCCCCCCCCCCC	42.29	24411173
156	Methylation	GGGGAGFRGAGKSEP CCCCCCCCCCCCCCC	32.89	24411181
161	Phosphorylation	GFRGAGKSEPSPSCS CCCCCCCCCCCCCCC	54.55	-
164	Phosphorylation	GAGKSEPSPSCSPSM CCCCCCCCCCCCCCC	25.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NANO3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NANO3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NANO3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNOT1_HUMAN	CNOT1	physical	24736845
CNOT3_HUMAN	CNOT3	physical	24736845

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.