NANO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NANO1_HUMAN
• UniProt AC: Q8WY41
• Protein Name: Nanos homolog 1
• Gene Name: NANOS1
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Cytoplasm, perinuclear region . Cytoplasm . Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
• Protein Description: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion..
• Protein Sequence: MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRGRYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATTTSEATPREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AFPWAPRSPRRGRAP CCCCCCCCCCCCCCC	23.00	25106551
125	Phosphorylation	SRGRYLGSALELRAL CCHHCHHHHHHHHHH	27.38	27732954
152	Phosphorylation	EERFAELSPFAGRAA HHHHHHHCCCCHHHH	14.96	24719451
289	Ubiquitination	ARDGPPGKKLR---- CCCCCCCCCCC----	55.17	-
290	Ubiquitination	RDGPPGKKLR----- CCCCCCCCCC-----	56.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NANO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NANO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNOT1_HUMAN	CNOT1	physical	24736845
CNOT3_HUMAN	CNOT3	physical	24736845

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.