NAGA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAGA_HUMAN
• UniProt AC: Q9Y303
• Protein Name: N-acetylglucosamine-6-phosphate deacetylase {ECO:0000305|PubMed:22692205}
• Gene Name: AMDHD2
• Organism: Homo sapiens (Human).
• Sequence Length: 409
• Protein Description: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded..
• Protein Sequence: MRGEQGAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Dimethylation	------MRGEQGAAG ------CCCCCCCCC	58.31	-
19	Dimethylation	VLQFTNCRILRGGKL EEEECCCEEEECCEE	32.80	-
25	Ubiquitination	CRILRGGKLLREDLW CEEEECCEECCCCCE	47.36	-
43	Ubiquitination	GRILDPEKLFFEERR CEECCHHHHHHCCHH	56.85	2190698
43 (in isoform 1)	Ubiquitination	-	56.85	21906983
43 (in isoform 2)	Ubiquitination	-	56.85	21906983
120	Ubiquitination	SPPEVYHKVVPQIPV CCHHHHCCCCCCCCC	27.52	-
128	Ubiquitination	VVPQIPVKSGGPHGA CCCCCCCCCCCCCCC	37.72	-
321	Phosphorylation	EVDGLTAYVAGTKTL EECCEEEEEEECEEC	5.89	27642862
321 (in isoform 2)	Phosphorylation	-	5.89	25849741
321 (in isoform 3)	Phosphorylation	-	5.89	25849741
326	Ubiquitination	TAYVAGTKTLSGSIA EEEEEECEECCCCCC	46.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAGA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAGA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAGA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNPI2_HUMAN	GNPDA2	physical	25416956
GNPI1_HUMAN	GNPDA1	physical	26344197
GNPI2_HUMAN	GNPDA2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.