NAF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAF1_DROME
• UniProt AC: Q9VJ62
• Protein Name: H/ACA ribonucleoprotein complex non-core subunit NAF1
• Gene Name: CG10341
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 564
• Subcellular Localization: Nucleus.
• Protein Description: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1/CG4038 to yield mature H/ACA snoRNPs complex (By similarity)..
• Protein Sequence: MESEQPAAVKASAPIEEPQSTETAVELGKHSTLKADLSIDKLETATTEATNAVVEPVEMEQQVENELVNESTQAMTSTTTQEKVVGSVNNLVEEQQCVEMEFETSSDLVVQGSPSEESKKVASDASATVTAPQVQPAPHVDSSPQASGLSLLAAYSSDDSDDEKVTPVQNGDNDVIEVPVTDPASSTTAYRPVVAVSSDDESSKSSSSSSDSDSDSEGEYLTVLRKKIDKRINTVDCDEDDEDFDEDGATGDRSRRRQPPKVRGEMLLDDLPPIHQLEITVPEDECVELGKVQSIVDQLVLVSVLPNSMLFDLDTVLFLEKGRKVLGEVFDVLGQVSDPLYCVRFNSNKQILDRGIKIGDVVYCAPKTEHTQFVILSKLMQVRGSDASWEHDVEPPARYVDHSDDEEEREARAEQRKRRQRDRTNSTDSVDTVTSVATTATKASSVAPPPRQRGRRGQRESFRQSQRPSINQHNQNQPQDEQYNFHPSYNPGSWHSNYYQNYHQAAANFNMAQQHPGMPFPVPNYGYGMPYAMPPMYPHMYPPPPPFAPPPPNNQSHQGQPPPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	STLKADLSIDKLETA CCCCCCCCCCCHHHH	29.32	19429919
234	Phosphorylation	KIDKRINTVDCDEDD HCCCCCCCCCCCCCC	18.49	21082442
250	Phosphorylation	DFDEDGATGDRSRRR CCCCCCCCCCHHHCC	45.18	18327897
254	Phosphorylation	DGATGDRSRRRQPPK CCCCCCHHHCCCCCC	34.57	18327897
385	Phosphorylation	KLMQVRGSDASWEHD HHHHHCCCCCCCCCC	21.31	19429919
388	Phosphorylation	QVRGSDASWEHDVEP HHCCCCCCCCCCCCC	37.68	19429919
399	Phosphorylation	DVEPPARYVDHSDDE CCCCCCCCCCCCCCH	16.61	19060867
403	Phosphorylation	PARYVDHSDDEEERE CCCCCCCCCCHHHHH	42.15	21082442
424	Phosphorylation	KRRQRDRTNSTDSVD HHHHHHCCCCCCCCH	37.50	19429919
426	Phosphorylation	RQRDRTNSTDSVDTV HHHHCCCCCCCCHHH	32.74	19429919
427	Phosphorylation	QRDRTNSTDSVDTVT HHHCCCCCCCCHHHH	34.07	19429919
429	Phosphorylation	DRTNSTDSVDTVTSV HCCCCCCCCHHHHHH	23.21	19429919
432	Phosphorylation	NSTDSVDTVTSVATT CCCCCCHHHHHHHHC	24.43	19429919
434	Phosphorylation	TDSVDTVTSVATTAT CCCCHHHHHHHHCCC	21.41	19429919
435	Phosphorylation	DSVDTVTSVATTATK CCCHHHHHHHHCCCH	12.86	19429919
438	Phosphorylation	DTVTSVATTATKASS HHHHHHHHCCCHHHH	18.14	19429919
439	Phosphorylation	TVTSVATTATKASSV HHHHHHHCCCHHHHC	23.69	19429919
441	Phosphorylation	TSVATTATKASSVAP HHHHHCCCHHHHCCC	25.67	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP58_DROME	Nup58	physical	14605208
POXM_DROME	Poxm	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-250; SER-254; SER-403;THR-427; SER-429 AND THR-432, AND MASS SPECTROMETRY.
PubMed: 18327897