MYO6_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO6_ARATH
• UniProt AC: Q9LKB9
• Protein Name: Myosin-6
• Gene Name: XI-2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1505
• Subcellular Localization: Cytoplasm . Colocalizes with peroxisome and cytoplasmic vesicles.
• Protein Description: Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in the tip growth of root hair cells. Plays a major role in trafficking of Golgi stacks, mitochondria and peroxisomes during root hair development. Targets the peroxisome through an interaction with RABC2A. Required for development of pavement cells, trichomes, and stigmatic papillae..
• Protein Sequence: MVANFNPSVGSFVWVEDPDEAWIDGEVVQVNGDEIKVLCTSGKHVVTKISNAYPKDVEAPASGVDDMTRLAYLHEPGVLQNLHSRYDINEIYTYTGSILIAVNPFRRLPHLYSSHMMAQYKGASLGELSPHPFAVADAAYRQMINDGVSQSILVSGESGAGKTESTKLLMRYLAYMGGRAAAEGRSVEQKVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDEKGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPQEDVKKFKLEEPKKYHYLNQSKCLELDSINDAEEYHATRRAMDVVGISTEEQDAIFSVVAAILHIGNIEFAKGEEIDSSIPKDDKSLFHLKTAAELLSCDEKALEDSLCKRIMVTRDETITKTLDPEAATLSRDALAKVMYSRLFDWLVDKINSSIGQDHDSKYLIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYKKEEINWSYIEFVDNQDILDLIEKKPGGIIALLDEACMFPRSTHETFAQKLYQTFKTHKRFTKPKLARSDFTICHYAGDVTYQTELFLDKNKDYVIAEHQALLNSSSCSFVASLFPPMSDDSKQSKFSSIGTRFKQQLVSLLEILNTTEPHYIRCIKPNNLLKPGIFENENILQQLRCGGVMEAIRISCAGYPTRKHFDEFLARFGILAPEVLVKNSDDPAACKKLLDKVGLEGYQIGKTKVFLRAGQMADLDTRRTEVLGRSASIIQRKVRSYLAKKSFIVLRNSAKQIQSVCRGYLARSVYEGMRREAAALKIQRDLRRFLARKAYTELYSAAVSVQAGMRGMVARKELCFRRQTKAAIIIQTWCRGYLARLHYRKLKKAAITTQCAWRSKVARGELRKLKMAARETGALQAAKNKLEKQVEELTWRLQLEKRIRTDLEEAKKQESAKAQSSLEELQLKCKETEALLIKEREAAKKIAETAPIIKEIPVVDQELMDKITNENEKLKSMVSSLEMKIGETEKKLQETTKISQDRLNQALEAESKLVKLKTAMQRLEEKILDMEAEKKIMHQQTISTPVRTNLGHPPTAPVKNLENGHQTNLEKEFNEAEFTTPVDGKAGKSAAERQIMNVDALIDCVKDNIGFSNGKPVAAFTIYKCLLHWKCFESEKTNVFDRLIQMIGSAIENEDDNSHLAYWLTSTSALLFLLQKSLKTNGSGATQSKKPPASTSLFGRMAMSFRSSPASGNLAAAAEAAALAVVRPVEAKYPALLFKQQLAAYVEKMFGMVRDNLKRELSTLLSLCIQAPRSSKGGMLRSGRSFGKDSPAVHWQSIIDGLNSLLVTLKENHVPLVLIQKIYSQTFSYINVQLFNSLLLRKECCTFSNGEFVKSGLAELELWCCQAKEYSGPSWEELKHIRQAVGFLVIHQKYRISYDEIANDLCPVLSVQQLYRICTLYWDDSYNTRSVSQEVISSMRTLMTEESNDADSDSFLLDDDSSIPFSIDDISSSMEEKDFVGIKPAEELLENPAFVFLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
236	Phosphorylation	ISGAAIRTYLLERSR CCHHHHHHHHHHHCC		19880383
242	Phosphorylation	RTYLLERSRVCQVSD HHHHHHHCCCCCCCC		24894044
1211	Phosphorylation	LFGRMAMSFRSSPAS HHHHHHHHCCCCCCC		29654922
1214	Phosphorylation	RMAMSFRSSPASGNL HHHHHCCCCCCCCCH		27288362
1215	Phosphorylation	MAMSFRSSPASGNLA HHHHCCCCCCCCCHH		27288362
1218	Phosphorylation	SFRSSPASGNLAAAA HCCCCCCCCCHHHHH		27288362

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO6_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RABD1_ARATH	ATFP8	physical	18703495
RAC2A_ARATH	RABC2A	physical	18703495
DCP1_ARATH	DCP1	physical	24525673

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.