dbPTM

MUT7_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MUT7_DROME
UniProt AC	Q9VIF1
Protein Name	Exonuclease mut-7 homolog
Gene Name	Nbr
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	625
Subcellular Localization
Protein Description	Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation..
Protein Sequence	MARKSHMYNAIPAGFESDEENMENLMSNLKIKRLEDITTGAGIDGCNFDATLDAKAEEFFKLFREKWNMYSKKKSPHLRQEFGRALMGHQDPLLLALKIFANCPDSSNIKTKSLSHFVLDTVCKLHKDFPHLGEGCDPNTSMIAFNFVKTSGLLALNNAVIHAYSLRQIRDLLLPKLRELLDNGLYKEVTQWSISLQLTHEFDMLELAFPLIAIEKLPLAEEYLDHATQQRLPFVKFLDSLLHKEKSVLELCEHLLDRYKNLKISHNVLSYRPMAKIVARLAKKYGFDDAVTPNYKFTKTCSYLHYLYREYEKTRMNLASFREVVSVHAFNHELRTDFVKYLASAGAHSEAIYWYTEFNIDPKDCPLEIETQVSQNGAGKASGWESPGKERCPSSRCDMYLTMDLPDECLIIVNKADEFDRMLYHLQQECVIYLDSEWMQSVCGDNQLCVLQIATGHNVYLIDCLARESLRSEHWRLLGANIFNNVNIRKVGFSMVSDLSVLQRSLPLQLRLQMPHHYLDLRNLWLELKKQRFGVELPFGNVNRAGDALTDLSLACLGKKLNKSNQCSNWANRPLRREQILYAAIDARCLMLIYNTLIERVSFIQAVIEKSIASNNFLRRGAHVK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MARKSHMYNAIP ---CCCHHHHCCCCC	14.13	19429919
8	Phosphorylation	MARKSHMYNAIPAGF CCCHHHHCCCCCCCC	8.95	23607784
17	Phosphorylation	AIPAGFESDEENMEN CCCCCCCCCHHHHHH	48.32	19429919
27	Phosphorylation	ENMENLMSNLKIKRL HHHHHHHHHCCCCCH	42.02	23607784
386	Phosphorylation	GKASGWESPGKERCP CCCCCCCCCCCCCCC	32.23	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MUT7_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MUT7_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MUT7_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PIWI_DROME	piwi	physical	26718004
PIWI_DROME	piwi	physical	27851737

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MUT7_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.	18327897 [Abstract]