MTRM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTRM_DROME
• UniProt AC: Q23973
• Protein Name: Protein matrimony {ECO:0000303|PubMed:14573476}
• Gene Name: mtrm {ECO:0000303|PubMed:14573476}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 217
• Subcellular Localization: Nucleus . Chromosome .
• Protein Description: Polo kinase inhibitor required to maintain G2 arrest in the meiotic cell cycle in females. [PubMed: 18052611 Holds heterochromatically paired homologs together from the end of pachytene until metaphase I]
• Protein Sequence: MENSRTPTNKTKITLNRTPTLKERRWNTLKVNTSNVRCSTPIFGNFRSPNLSPIENMGTKGKSPVSPMRFATFKKVPTKVHPKQQQQQQHQHCHRTQLKPPPFVLPKPQEEIIEPEREIKSCSSPDTCSDDSNMETSLALESRRRSIKASNHSYVVNHAANVEQILMHMGLENYVTNFEEAHIDLVELASLERADLVKIGLNTDEDCNRIMDVLHTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	PTNKTKITLNRTPTL CCCCCEEEECCCCCH	21.38	28490779
18	Phosphorylation	TKITLNRTPTLKERR CEEEECCCCCHHHHH	21.39	28490779
20	Phosphorylation	ITLNRTPTLKERRWN EEECCCCCHHHHHCC	50.26	28490779
48	Phosphorylation	PIFGNFRSPNLSPIE CCCCCCCCCCCCCCC	17.63	30478224
52	Phosphorylation	NFRSPNLSPIENMGT CCCCCCCCCCCCCCC	30.39	30478224
63	Phosphorylation	NMGTKGKSPVSPMRF CCCCCCCCCCCCCCC	38.92	22817900
66	Phosphorylation	TKGKSPVSPMRFATF CCCCCCCCCCCCCEE	19.16	24019759

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTRM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTRM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTRM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTRO_DROME	Patronin	physical	14605208
CORT_DROME	cort	physical	24019759
POLO_DROME	polo	genetic	18052611
POLO_DROME	polo	physical	23479640

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-66, AND MASSSPECTROMETRY.
PubMed: 18327897