dbPTM

MOS1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MOS1_ARATH
UniProt AC	Q9SB63
Protein Name	Protein MODIFIER OF SNC1 1
Gene Name	MOS1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1412
Subcellular Localization
Protein Description	Involved in the regulation of the chromatin structure and DNA methylation at the SNC1 locus. Regulates the expression of SNC1 at chromatin level..
Protein Sequence	MTSSTTGDRRWGTTRRSGMTILGKVAVPKPINLPSQRLENQGLDPNVEIVPKGTLSWGSKSSLNAWGTSSLSPRTESGPGSPSHLSNRPSSGGSVTRPSTADSNKAHDSSSSVAWDSNSRPSSASGVFPSNQPSVALQRPHSADTRPGSSQLSRFAEPVSETSATWGQHVAPEKLGVAPSKNDGFSLTSGDFPSLGAEKDTSEKSTRPQDAGPHARPPSSSGRSVEGQGVDCTEEANDRIGDANSWRRENQPYSEDAPRHCREEGQLDSRGSQSYPNANFPPRYDAWRGPPVNNHQGGGWYGGNHPYGAPMGPGGFHMDPFPFYPTQVPPAPGHGAGPRGNHANNERMFRPPMLDSYVHPRMQTRPGFYVGPAPHEGYYGPPMGYGSPSNRDLPFAGRPTGPHAYNNHSGQGGYDTPGSSVSLERNESSHSQETQRPYKVLLKHQDGRFGEDNAKREEFLGNRLPNAEKIAQQMQTSRNERREIRNDASGEVQPVKAELAAPGDPSLIQKIEGLNAKTRTNDGWQNSSSVVNRDEQESQPRTLNSGNSANKVSARNHRTGHASDSKNSSHYNQGDSATNKNAEPAAMGGTSIFRRPTQQTQGRADPQTKRIVNSEGNDAWQKTTVMSGSSHTTLATNTESFREVNVDDSLDTESIRRPGSGISADPKDNQRSTMRELARQRAQQRQKEEEERARDQRAKALAKLEELNRRSQIYEEGSVKNMEAASNASPADMPTDPGSHSSNATNSVEPTGGSGKNTTQNTRTSTEYANNVGPSQQDNLPRDGGASKQKRLGYKQKQNIIFEKKPTGSSVATAEVFDVVPSPEVVNEGVSSNNSDMPATSTVSAESTFPKRKNNRNGKKKHKAEETATMNTTRVAVGKETKSGDESIETARARAAEIELGSVSVPSLDIKVSGDSSEQISSFTNEESQNRAKNNWKSQHVRRTQRNSLVNKPAEKFSGNNAVIWAPVHPQQKADVSTGGGSQTTVPEFGTSSKSQHQGQTSSKSKRVEIERYVPKPIVKEMAEQIVSKNLVTSAPDMSENVNQKENRGGEGTGILQPSGSTAGKSGSPSKSRHGNGRQGKHGREHASWHQRGSGAPTKALEDGQFVTSNQPIRGTVNYHSSKQTEQIAAKDQTTCNKDGWNDGWYMTPETHYSAAEEMESSAVGKDQGMSMHGRQHASRSNKDGGSNYGDPKKGNKRDFNKAHTQHSGHGFSQPDLPAASKEGRVPGDHVWHTANRTGKYGGRESTRDKPYGSQEKNVVGYEHQGFTTEQKTTSADTQAQLQNRSTNKEVQVEQNPNSMFQKNTGQGRRFGRGQESQGGWGLPAQENMHHHHQRPPSNRDRQKQNLHYEYKPVGSHTYDGERSREQSKESSQTEGPRYREKGQGQQRQGGYQQQRGTSGRNGGHGFTGDRN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	IVPKGTLSWGSKSSL ECCCCCCCCCCCCCC	29.27	19880383
59	Phosphorylation	KGTLSWGSKSSLNAW CCCCCCCCCCCCCCC	24.09	25561503
61	Phosphorylation	TLSWGSKSSLNAWGT CCCCCCCCCCCCCCC	41.58	19376835
62	Phosphorylation	LSWGSKSSLNAWGTS CCCCCCCCCCCCCCC	29.40	19376835
68	Phosphorylation	SSLNAWGTSSLSPRT CCCCCCCCCCCCCCC	12.39	23776212
69	Phosphorylation	SLNAWGTSSLSPRTE CCCCCCCCCCCCCCC	25.91	23776212
70	Phosphorylation	LNAWGTSSLSPRTES CCCCCCCCCCCCCCC	32.48	23776212
72	Phosphorylation	AWGTSSLSPRTESGP CCCCCCCCCCCCCCC	17.81	30291188
75	Phosphorylation	TSSLSPRTESGPGSP CCCCCCCCCCCCCCH	37.58	23660473
77	Phosphorylation	SLSPRTESGPGSPSH CCCCCCCCCCCCHHH	50.07	23660473
81	Phosphorylation	RTESGPGSPSHLSNR CCCCCCCCHHHHCCC	26.77	27531888
83	Phosphorylation	ESGPGSPSHLSNRPS CCCCCCHHHHCCCCC	38.46	23660473
86	Phosphorylation	PGSPSHLSNRPSSGG CCCHHHHCCCCCCCC	25.93	23660473
90	Phosphorylation	SHLSNRPSSGGSVTR HHHCCCCCCCCCCCC	38.08	23660473
91	Phosphorylation	HLSNRPSSGGSVTRP HHCCCCCCCCCCCCC	50.27	23660473
94	Phosphorylation	NRPSSGGSVTRPSTA CCCCCCCCCCCCCCC	24.68	23660473
96	Phosphorylation	PSSGGSVTRPSTADS CCCCCCCCCCCCCCC	38.26	23660473
99	Phosphorylation	GGSVTRPSTADSNKA CCCCCCCCCCCCCCC	32.70	23660473
100	Phosphorylation	GSVTRPSTADSNKAH CCCCCCCCCCCCCCC	36.85	23660473
103	Phosphorylation	TRPSTADSNKAHDSS CCCCCCCCCCCCCCC	37.45	23660473
142	Phosphorylation	VALQRPHSADTRPGS EECCCCCCCCCCCCC	30.44	29654922
145	Phosphorylation	QRPHSADTRPGSSQL CCCCCCCCCCCCCHH	38.18	25561503
149	Phosphorylation	SADTRPGSSQLSRFA CCCCCCCCCHHHHHC	20.00	25561503
150	Phosphorylation	ADTRPGSSQLSRFAE CCCCCCCCHHHHHCC	40.84	25561503
153	Phosphorylation	RPGSSQLSRFAEPVS CCCCCHHHHHCCCCC	20.09	25561503
224	Phosphorylation	PPSSSGRSVEGQGVD CCCCCCCCCCCCCCC	28.22	23776212
428	Phosphorylation	VSLERNESSHSQETQ EEEECCCCCCCCCCC	36.58	25561503
429	Phosphorylation	SLERNESSHSQETQR EEECCCCCCCCCCCC	22.45	25561503
623	Phosphorylation	GNDAWQKTTVMSGSS CCCHHHEEEEECCCC	14.99	19880383
624	Phosphorylation	NDAWQKTTVMSGSSH CCHHHEEEEECCCCC	22.65	19880383
660	Phosphorylation	ESIRRPGSGISADPK HHCCCCCCCCCCCCC	35.32	27545962
663	Phosphorylation	RRPGSGISADPKDNQ CCCCCCCCCCCCCCH	30.09	19880383
714	Phosphorylation	LNRRSQIYEEGSVKN HHHHHHHHHCCCCCC	10.57	25561503
718	Phosphorylation	SQIYEEGSVKNMEAA HHHHHCCCCCCHHHH	32.95	25561503
881	Phosphorylation	RVAVGKETKSGDESI EEEECCCCCCCCHHH	33.71	23776212
883	Phosphorylation	AVGKETKSGDESIET EECCCCCCCCHHHHH	59.92	19880383
887	Phosphorylation	ETKSGDESIETARAR CCCCCCHHHHHHHHH	30.39	23776212
890	Phosphorylation	SGDESIETARARAAE CCCHHHHHHHHHHHE	21.55	23776212
902	Phosphorylation	AAEIELGSVSVPSLD HHEEEECCEECCCCE	24.68	28011693
904	Phosphorylation	EIELGSVSVPSLDIK EEEECCEECCCCEEE	29.97	28011693
1053	Phosphorylation	ENRGGEGTGILQPSG CCCCCCCCCCCCCCC	19.42	19376835
1059	Phosphorylation	GTGILQPSGSTAGKS CCCCCCCCCCCCCCC	32.20	19376835
1061	Phosphorylation	GILQPSGSTAGKSGS CCCCCCCCCCCCCCC	21.30	25368622
1062	Phosphorylation	ILQPSGSTAGKSGSP CCCCCCCCCCCCCCC	42.85	25368622
1066	Phosphorylation	SGSTAGKSGSPSKSR CCCCCCCCCCCCCCC	43.52	25368622
1068	Phosphorylation	STAGKSGSPSKSRHG CCCCCCCCCCCCCCC	32.84	25368622
1070	Phosphorylation	AGKSGSPSKSRHGNG CCCCCCCCCCCCCCC	44.98	25368622
1072	Phosphorylation	KSGSPSKSRHGNGRQ CCCCCCCCCCCCCCC	33.57	25368622
1187	Phosphorylation	RSNKDGGSNYGDPKK CCCCCCCCCCCCCCC	32.20	30407730
1254	Phosphorylation	TRDKPYGSQEKNVVG CCCCCCCCCCCCCCC	29.35	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MOS1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MOS1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MOS1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MAD2_ARATH	MAD2	physical	25429892
SUF4_ARATH	SUF4	physical	25429892

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MOS1_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72 AND SER-883, AND MASSSPECTROMETRY.	19376835 [Abstract]