MOM1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOM1_ARATH
• UniProt AC: Q9M658
• Protein Name: Helicase protein MOM1
• Gene Name: MOM1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 2001
• Subcellular Localization: Nucleus .
• Protein Description: Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-mediated TGS pathway), probably by modulating small interfering RNA (siRNA) accumulation. Especially involved in the gene silencing of the transcriptionally silent information region (TSI), 5S ribosomal RNA genes (localized in the pericentromeric heterochromatin of chromosomes 3, 4, and 5) and of 180-bp satellite repeats and 106B long terminal repeat (LTR)-like repeats of the chromocenters. Prevents the aberrant mRNA transcriptional read-through..
• Protein Sequence: MKKDEKIGLTGRTIYTRSLAASIPASVEQETPGLRRSSRGTPSTKVITPASATRKSERLAPSPASVSKKSGGIVKNSTPSSLRRSNRGKTEVSLQSSKGSDNSIRKGDTSPDIEQRKDSVEESTDKIKPIMSARSYRALFRGKLKESEALVDASPNEEELVVVGCSRRIPAGNDDVQGKTDCPPPADAGSKRLPVDETSLDKGTDFPLKSVTETEKIVLDASPIVETGDDSVIGSPSENLETQKLQDGKTDCSPPANAESKTLPVGETSLEKEYPQKFQDDNTDCLPPANAESKRLPVGETSLEKDTDFPLKSTTETGKMVLYASPIVETRDDSVICSPSTNLETQKLLVSKTGLETDIVLPLKRKRDTAEIELDACATVANGDDHVMSSDGVIPSPSGCKNDNRPEMCNTCKKRQKVNGDCQNRSVCSCIVQPVEESDNVTQDMKETGPVTSREYEENGQIQHGKSSDPKFYSSVYPEYWVPVQLSDVQLEQYCQTLFSKSLSLSSLSKIDLGALEETLNSVRKTCDHPYVMDASLKQLLTKNLELHEILDVEIKASGKLHLLDKMLTHIKKNGLKAVVFYQATQTPEGLLLGNILEDFVGQRFGPKSYEHGIYSSKKNSAINNFNKESQCCVLLLETRACSQTIKLLRADAFILFGSSLNPSHDVKHVEKIKIESCSERTKIFRLYSVCTVEEKALILARQNKRQNKAVENLNRSLTHALLMWGASYLFDKLDHFHSSETPDSGVSFEQSIMDGVIHEFSSILSSKGGEENEVKLCLLLEAKHAQGTYSSDSTLFGEDHIKLSDEESPNIFWSKLLGGKNPMWKYPSDTPQRNRKRVQYFEGSEASPKTGDGGNAKKRKKASDDVTDPRVTDPPVDDDERKASGKDHMGALESPKVITLQSSCKSSGTDGTLDGNDAFGLYSMGSHISGIPEDMLASQDWGKIPDESQRRLHTVLKPKMAKLCQVLHLSDACTSMVGNFLEYVIENHRIYEEPATTFQAFQIALSWIAALLVKQILSHKESLVRANSELAFKCSRVEVDYIYSILSCMKSLFLEHTQGLQFDCFGTNSKQSVVSTKLVNESLSGATVRDEKINTKSMRNSSEDEECMTEKRCSHYSTATRDIEKTISGIKKKYKKQVQKLVQEHEEKKMELLNMYADKKQKLETSKSVEAAVIRITCSRTSTQVGDLKLLDHNYERKFDEIKSEKNECLKSLEQMHDVAKKKLAEDEACWINRIKSWAAKLKVCVPIQSGNNKHFSGSSNISQNAPDVQICNNANVEATYADTNCMASKVNQVPEAENTLGTMSGGSTQQVHEMVDVRNDETMDVSALSREQLTKSQSNEHASITVPEILIPADCQEEFAALNVHLSEDQNCDRITSAASDEDVSSRVPEVSQSLENLSASPEFSLNREEALVTTENRRTSHVGFDTDNILDQQNREDCSLDQEIPDELAMPVQHLASVVETRGAAESDQYGQDICPMPSSLAGKQPDPAANTESENLEEAIEPQSAGSETVETTDFAASHQGDQVTCPLLSSPTGNQPAPEANIEGQNINTSAEPHVAGPDAVESGDYAVIDQETMGAQDACSLPSGSVGTQSDLGANIEGQNVTTVAQLPTDGSDAVVTGGSPVSDQCAQDASPMPLSSPGNHPDTAVNIEGLDNTSVAEPHISGSDACEMEISEPGPQVERSTFANLFHEGGVEHSAGVTALVPSLLNNGTEQIAVQPVPQIPFPVFNDPFLHELEKLRRESENSKKTFEEKKSILKAELERKMAEVQAEFRRKFHEVEAEHNTRTTKIEKDKNLVIMNKLLANAFLSKCTDKKVSPSGAPRGKIQQLAQRAAQVSALRNYIAPQQLQASSFPAPALVSAPLQLQQSSFPAPGPAPLQPQASSFPSSVSRPSALLLNFAVCPMPQPRQPLISNIAPTPSVTPATNPGLRSPAPHLNSYRPSSSTPVATATPTSSVPPQALTYSAVSIQQQQEQQPQQSLSSGLQSNNEVVCLSDDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	NSIRKGDTSPDIEQR CCCCCCCCCCCHHHH	51.32	25561503
110	Phosphorylation	SIRKGDTSPDIEQRK CCCCCCCCCCHHHHH	25.89	25561503
132	Phosphorylation	DKIKPIMSARSYRAL HHCHHCHHHHHHHHH	22.65	24894044
222	Phosphorylation	EKIVLDASPIVETGD EEEEEECCCCEECCC	18.15	30407730
227	Phosphorylation	DASPIVETGDDSVIG ECCCCEECCCCCCCC	34.71	30407730
231	Phosphorylation	IVETGDDSVIGSPSE CEECCCCCCCCCCCC	22.00	30407730
235	Phosphorylation	GDDSVIGSPSENLET CCCCCCCCCCCCCCC	17.71	30407730
237	Phosphorylation	DSVIGSPSENLETQK CCCCCCCCCCCCCCC	40.59	30407730
569	Phosphorylation	HLLDKMLTHIKKNGL HHHHHHHHHHHHCCE	20.32	19880383
848	Phosphorylation	YFEGSEASPKTGDGG EEECCCCCCCCCCCC	23.91	25561503
895	Phosphorylation	DHMGALESPKVITLQ CCCHHHCCCCEEEEE	30.76	25561503
1345	Phosphorylation	SQSNEHASITVPEIL CCCCCCCCEECCEEE	22.24	28011693
1347	Phosphorylation	SNEHASITVPEILIP CCCCCCEECCEEEEE	27.75	28011693
1379	Phosphorylation	QNCDRITSAASDEDV CCCCHHHHCCCCCCH	21.33	19880383
1382	Phosphorylation	DRITSAASDEDVSSR CHHHHCCCCCCHHHC	41.05	27531888
1394	Phosphorylation	SSRVPEVSQSLENLS HHCCHHHHHHHHHHC	16.64	30407730
1396	Phosphorylation	RVPEVSQSLENLSAS CCHHHHHHHHHHCCC	30.09	30407730
1401	Phosphorylation	SQSLENLSASPEFSL HHHHHHHCCCCCCCC	37.98	30407730
1403	Phosphorylation	SLENLSASPEFSLNR HHHHHCCCCCCCCCH	22.91	30291188
1407	Phosphorylation	LSASPEFSLNREEAL HCCCCCCCCCHHHEE	24.07	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOM1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOM1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOM1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCP14_ARATH	TCP14	physical	21798944
SEC_ARATH	SEC	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.