dbPTM

MKS1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MKS1_ARATH
UniProt AC	Q8LGD5
Protein Name	Protein MKS1
Gene Name	MKS1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	222
Subcellular Localization	Nucleus .
Protein Description	Regulator of plant defense response. May contribute to MPK4-regulated defense activation by coupling the kinase to specific WRKY transcription factors..
Protein Sequence	MDPSEYFAGGNPSDQQNQKRQLQICGPRPSPLSVHKDSHKIKKPPKHPAPPPNRDQPPPYIPREPVVIYAVSPKVVHATASEFMNVVQRLTGISSGVFLESGGGGDVSPAARLASTENASPRGGKEPAARDETVEINTAMEEAAEFGGYAPGILSPSPALLPTASTGIFSPMYHQGGMFSPAIPLGLFSPAGFMSPFRSPGFTSLVASPTFADFFSHIWDQD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	QICGPRPSPLSVHKD EECCCCCCCCCCCCC	39.49	15990873
72	Phosphorylation	PVVIYAVSPKVVHAT CEEEEEECCHHHHHH	15.72	17702678
91	Phosphorylation	MNVVQRLTGISSGVF HHHHHHHHCCCCCEE	34.36	27545962
94	Phosphorylation	VQRLTGISSGVFLES HHHHHCCCCCEEEEC	23.53	27545962
95	Phosphorylation	QRLTGISSGVFLESG HHHHCCCCCEEEECC	36.74	27545962
101	Phosphorylation	SSGVFLESGGGGDVS CCCEEEECCCCCCCC	44.90	27545962
108	Phosphorylation	SGGGGDVSPAARLAS CCCCCCCCHHHHHHC	17.35	27545962
120	Phosphorylation	LASTENASPRGGKEP HHCCCCCCCCCCCCC	27.06	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MKS1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MKS1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MKS1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WRK33_ARATH	WRKY33	physical	18650934
MPK4_ARATH	MPK4	physical	15990873
WRK25_ARATH	WRKY25	physical	15990873
WRK33_ARATH	WRKY33	physical	15990873

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MKS1_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND MASSSPECTROMETRY.	19376835 [Abstract]
"Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS1)."; Caspersen M.B., Qiu J.-L., Zhang X., Andreasson E., Naested H.,Mundy J., Svensson B.; Biochim. Biophys. Acta 1774:1156-1163(2007). Cited for: PHOSPHORYLATION AT SER72; SER108 AND SER120.	17702678 [Abstract]