MK07_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MK07_MOUSE
• UniProt AC: Q9WVS8
• Protein Name: Mitogen-activated protein kinase 7
• Gene Name: Mapk7
• Organism: Mus musculus (Mouse).
• Sequence Length: 806
• Subcellular Localization: Cytoplasm . Nucleus . Nucleus, PML body. Translocates to the nucleus upon activation..; Isoform 1: Cytoplasm. Nucleus. Isoform 1 is detected in cytoplasm and nucleus..; Isoform 2: Nucleus. Isoform 2 is detected only in the nucleus. Transloc
• Protein Description: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity)..
• Protein Sequence: MAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAPAPAPSSAQPTSTPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEPLKEED ------CCCCCCCCC	27.41	-
6	Sumoylation	--MAEPLKEEDGEDG --CCCCCCCCCCCCC	70.54	-
22	Sumoylation	GEPPGRVKAEPVHTA CCCCCCCCCCCCCCH	45.75	-
28	Phosphorylation	VKAEPVHTAASVVAK CCCCCCCCHHHHHHH	24.93	29514104
209	Phosphorylation	GMARGLCTSPAEHQY CCCCCCCCCHHHHHH	42.67	22499769
210	Phosphorylation	MARGLCTSPAEHQYF CCCCCCCCHHHHHHH	22.55	22499769
216	Phosphorylation	TSPAEHQYFMTEYVA CCHHHHHHHHHHHHH	9.38	22499769
219	Phosphorylation	AEHQYFMTEYVATRW HHHHHHHHHHHHHCH	17.79	22322096
221	Phosphorylation	HQYFMTEYVATRWYR HHHHHHHHHHHCHHC	6.04	22322096
224	Phosphorylation	FMTEYVATRWYRAPE HHHHHHHHCHHCCHH	16.22	22499769
322	Phosphorylation	GADRQALSLLGRMLR CCCHHHHHHHHHHHH	25.27	28059163
421	Phosphorylation	CPDVEMPSPWAPSGD CCCCCCCCCCCCCCC	31.59	22817900
433	Phosphorylation	SGDCAMESPPPALPP CCCCCCCCCCCCCCC	29.62	22817900
475	Phosphorylation	EGAISDNTKAALKAA CCCCCHHHHHHHHHH	27.35	25266776
486	Phosphorylation	LKAALLKSLRSRLRD HHHHHHHHHHHHHCC	29.05	22817900
496	Phosphorylation	SRLRDGPSAPLEAPE HHHCCCCCCCCCCCC	48.31	22817900
562	Phosphorylation	PLAGLVLSDNDRSLL CCCCEECCCCCHHHH	27.21	25338131
710	Phosphorylation	VTQQLSKSQVEDPLP HHHHHHHHHCCCCCC	35.76	28066266
721	Phosphorylation	DPLPPVFSGTPKGSG CCCCCCCCCCCCCCC	41.83	26824392
723	Phosphorylation	LPPVFSGTPKGSGAG CCCCCCCCCCCCCCC	22.19	26824392
760	Phosphorylation	PQDGQADSASLSASL CCCCCCCCHHHHHHH	23.83	22817900
764	Phosphorylation	QADSASLSASLLADW CCCCHHHHHHHHHHH	17.20	22817900
766	Phosphorylation	DSASLSASLLADWLE CCHHHHHHHHHHHHH	22.12	22817900
793	Phosphorylation	QREIQMDSPMLLSDL HHHHHCCCCCCHHCC	13.58	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
486	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
496	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
496	S	Phosphorylation	Kinase	P90RSK	P18653	PSP
723	T	Phosphorylation	Kinase	MAPK7	Q9WVS8	GPS
760	S	Phosphorylation	Kinase	MAPK7	Q9WVS8	GPS
764	S	Phosphorylation	Kinase	MAPK7	Q9WVS8	GPS
766	S	Phosphorylation	Kinase	MAPK7	Q9WVS8	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
219	T	Phosphorylation	Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MK07_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	20724525
HS90B_MOUSE	Hsp90ab1	physical	23428871
CDC37_MOUSE	Cdc37	physical	23428871
NF2L2_MOUSE	Nfe2l2	physical	23043106

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.