dbPTM

MGST2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MGST2_HUMAN
UniProt AC	Q99735
Protein Name	Microsomal glutathione S-transferase 2
Gene Name	MGST2
Organism	Homo sapiens (Human).
Sequence Length	147
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Microsome membrane Multi-pass membrane protein .
Protein Description	Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione..
Protein Sequence	MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LSACQQSYFALQVGK HHHHHHHHHHHHCCC	6.63	19702290
33	Phosphorylation	VGKARLKYKVTPPAV CCCCCCEEEECCCCC	18.45	24275569
34	Ubiquitination	GKARLKYKVTPPAVT CCCCCEEEECCCCCC	37.74	33845483
41	Phosphorylation	KVTPPAVTGSPEFER EECCCCCCCCHHHHH	33.76	29214152
43	Phosphorylation	TPPAVTGSPEFERVF CCCCCCCCHHHHHHH	16.34	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MGST2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MGST2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MGST2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MGST2_HUMAN	MGST2	physical	26066610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01008	Busulfan
DB00143	Glutathione

Regulatory Network of MGST2_HUMAN

Related Literatures of Post-Translational Modification