MET14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET14_HUMAN
• UniProt AC: Q9HCE5
• Protein Name: N6-adenosine-methyltransferase non-catalytic subunit {ECO:0000305}
• Gene Name: METTL14 {ECO:0000312|HGNC:HGNC:29330}
• Organism: Homo sapiens (Human).
• Sequence Length: 456
• Subcellular Localization: Nucleus .
• Protein Description: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. [PubMed: 24316715]
• Protein Sequence: MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	AQQLGAESADSIGAV HHHHCCCCHHHHHHH	36.52	24173317
30	Phosphorylation	LGAESADSIGAVLNS HCCCCHHHHHHHHCC	23.73	28348404
38	Ubiquitination	IGAVLNSKDEQREIA HHHHHCCHHHHHHHH	65.30	21906983
54	Phosphorylation	TRETCRASYDTSAPN HHHHHHHHCCCCCCC	12.28	28796482
55	Phosphorylation	RETCRASYDTSAPNA HHHHHHHCCCCCCCC	23.43	28796482
57	Phosphorylation	TCRASYDTSAPNAKR HHHHHCCCCCCCCCH	20.68	28796482
58	Phosphorylation	CRASYDTSAPNAKRK HHHHCCCCCCCCCHH	38.54	28796482
63	Acetylation	DTSAPNAKRKYLDEG CCCCCCCCHHHCCCC	56.94	25953088
72	Phosphorylation	KYLDEGETDEDKMEE HHCCCCCCCHHHHHH	56.39	25849741
80	Phosphorylation	DEDKMEEYKDELEMQ CHHHHHHHHHHHHHH	15.50	23898821
95	Phosphorylation	QDEENLPYEEEIYKD CCCCCCCCCHHHHCC	38.86	-
100	Phosphorylation	LPYEEEIYKDSSTFL CCCCHHHHCCCCHHH	16.42	-
108	Ubiquitination	KDSSTFLKGTQSLNP CCCCHHHCCCCCCCC	56.58	29967540
148	Ubiquitination	DRFEEYPKLRELIRL HHHHHCHHHHHHHHH	60.31	27667366
148	Acetylation	DRFEEYPKLRELIRL HHHHHCHHHHHHHHH	60.31	25953088
156	Ubiquitination	LRELIRLKDELIAKS HHHHHHHHHHHHHCC	39.03	27667366
185	Ubiquitination	DIRELTPKFDVILLE CHHHHCCCCCEEEEC	49.30	29967540
272	Phosphorylation	NKNNPGKTKTLDPKA CCCCCCCCCCCCHHH	34.87	20068231
278	Ubiquitination	KTKTLDPKAVFQRTK CCCCCCHHHHHHHHH	57.77	-
297	Ubiquitination	MGIKGTVKRSTDGDF CCCCCEEEECCCCCC	40.23	24816145
351	Phosphorylation	LHLFGRDSTIRPGWL HHHCCCCCCCCCCEE	25.11	23909892
352	Phosphorylation	HLFGRDSTIRPGWLT HHCCCCCCCCCCEEE	25.87	23909892
399	Phosphorylation	IERLRPKSPPPKSKS HHHHCCCCCCCCCCC	45.37	30266825
421	Phosphorylation	RGGGRGGTSAGRGRE CCCCCCCCCCCCCCC	20.44	25278378
422	Phosphorylation	GGGRGGTSAGRGRER CCCCCCCCCCCCCCC	31.81	25278378
442	Methylation	RGERGGFRGGRGGAH CCCCCCCCCCCCCCC	50.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNX15_HUMAN	SNX15	physical	22939629
SNF8_HUMAN	SNF8	physical	22939629
DDI2_HUMAN	DDI2	physical	26344197
MTA70_HUMAN	METTL3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.